Compositions of nutrition supplementation for nutritional deficiencies and method of use therefore
A nutritional supplement composition for treating nutritional deficiencies caused by a medical condition in subjects is disclosed. The present application further discloses a method of using a nutritional supplements composition for treating a subject with complications resulting from sickle cell anemia. The method comprises administering to a subject an effective amount of the nutritional supplement.
1. A method for providing nutritional support to a subject having sickle cell anemia, comprising:
orally administering to a subject in need of such treatment a daily nutritional supplement having total calories of about 700-980 kcal, wherein about 10-20% of the total calories are derived from protein, about 25-40% of the total calories are derived from fat, and about 45-65% of the total calories are derived from carbohydrate.
2. The method of claim 1 , wherein the nutritional supplement is administered orally in the form of a snack.
3. The method of claim 2 , wherein the nutritional supplement is administered orally as the last snack before sleeping.
4. The method of claim 2 , wherein the nutritional supplement is administered as snacks after each meal,
5. The method of claim 1 , wherein the nutritional supplement comprises:
protein in an amount that provides about 14% of the total calories;
fat in an amount that provides about 32% of the total calories; and
carbohydrate that provides about 54% of the total calories.
6. The method of claim 1 , wherein the nutritional supplement comprises about 24-34 grams of protein; about 25-35 grams of fat; and about 96-135 grams of carbohydrate.
7. The method of claim 1 , wherein the nutritional supplement further comprises at least one food grade amino acid selected from the group consisting of arginine, histidine, leucine, valine, cysteine and glutamine.
8. The method of claim 7 , wherein the nutritional supplement comprises arginine, histidine, leucine, valine, cysteine and glutamine, and wherein each amino acid is provided at a per diem dose range of 8-14 mg/kg body weight/day.
9. The method of claim 7 , wherein the nutritional supplement comprises arginine, histidine, leucine, valine, cysteine and glutamine, and wherein each amino acid is provided at a per diem dose range of 22-44 mg/kg body weight/day.
10. The method of claim 7 , wherein the nutritional supplement further comprises S-allyl cysteine, S-allylmercapto cysteine and fructosyl arginine.
11. The method of claim 7 , wherein the nutritional supplement further comprises a garlic extract.
12. The method of claim 1 , wherein the nutritional supplement further comprises one or more antioxidants.
13. The method of claim 12 , wherein the one or more antioxidants is selected from the group consisting of Vitamin A, Vitamin C, Vitamin E, β-carotene and selenium.
14. The method of claim 12 , wherein the one or more antioxidants comprise Vitamin C and Vitamin E.
15. The method of claim 1 , further comprising administering one or more nutrients selected from the group consisting of: Vitamin A 8,250-250,000 IU, Vitamin B-1 25-1000 mg, Vitamin B-2 25-1000 mg, Vitamin B-6 25-1000 mg, Vitamin B-12 25-1000 mcg, Vitamin C 25-1000 mg, Vitamin D 100-4000 IU, Vitamin E 25-1000 IU, Niacinamide 25-1000 mg, Para-aminobenzoic acid (PABA) 25-1000 mg, Pantothenic Acid 25-1000 mg, Choline Bitartrate 25-1000 mg, Inositol 25-1000 mg, Rutin 8.25-250 mg, Citrus Bioflavonoid Complex 8.25-250 mg, Betaine Hydrochloride 8.25-250 mg, Hesperidin Complex 1.25-50 mg, Folic Acid 100-4000 mcg, Biotin 25-1000 mcg, Calcium 10-400 mg, Iron 8.25-250 mg, Magnesium 5-100 mg, Zinc 5-100 mg, Potassium 3.75-150 mg, Manganese 1.5-60 mg, Iodine 37.5-1500 mcg, Chromium 3.75-150 mcg, and Selenium 2.5-100 mcg.
16. The method of claim 15 , further comprising administering one or more compound(s) selected from the group consisting of L-lysine-L-phenylalanine, L-lysine-L-tyrosine, L-histidine-L-lysine-L-tyrosine-L-histidine, and salts thereof at a dose range of 10-150 mg/kg/day.
17. The method of claim 15 , further comprising administering L-lysine-L-phenylalanine or a salt thereof at a dose range of 20-80 mg/kg/day.
18. The method of claim 1 , further comprising administering a thiocyanate in an amount of 100-500 mg.
19. The method of claim 18 , wherein the thiocyanate is mixed with Vitamin B6 at a weight ratio of about 20:1.
20. The method of claim 1 , wherein the nutritional supplement is administered in the form of a cookie.
21. A method for reducing the resting energy expenditure to free fat mass ratio in a subject having sickle cell anemia, comprising:
orally administering to a subject in need of such treatment a daily nutritional supplement having total calories of about 700-980 kcal, wherein about 10-20% of the total calories are derived from protein, about 25-40% of the total calories are derived from fat, and about 45-65% of the total calories are derived from carbohydrate.
22. A method for increasing the plasma amino acid level of at least one amino acid in a subject having sickle cell anemia, wherein the at least one amino acid is selected from the group consisting of glutamine, histidine, citrulline, arginine, valine, ornithine and cysteine,
the method comprising:
orally administering to a subject in need of such treatment a daily nutritional supplement having total calories of about 700-980 kcal, wherein about 10-20% of the total calories are derived from protein, about 25-40% of the total calories are derived from fat, and about 45-65% of the total calories are derived from carbohydrate.
23. the method of claim 1 , wherein the plasma level of reduced glutathione is increased relative to the plasma level of oxidized glutathione as a result of said nutritional support.