Pyrrolopyridine and pyrrolopyrimidine inhibitors of kinases

1. A compound having formula I

wherein

A is heteroaryl,

B is aryl, heteroaryl, heterocycloalkenyl, or —CH═CH—;

X is —CH 2 —, —NR 8 —, —O—, —S—, —S(O)—, or —SO 2 —;

Z is C—R 4b ;

m is 0, 1, or 2;

n is 1 or 2;

p is 0, 1, 2, 3, or 4;

R 1 is halogen, —OR 9 , or —NR 10 R 11 ;

R 2 and R 3 are independently hydrogen or C 1-8 -alkyl, wherein the C 1-8 alkyl is optionally substituted with aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-4 -alkoxy, —NH 2 , —NH(C 1-4 -alkyl), or —N(C 1-4 -alkyl) 2 ;

R 4a and R 4b are independently hydrogen, nitro, halogen, cyano, C 1-4 -alkyl, C 1-4 -haloalkyl, —OR a , —NR b R c ; —C(O)OR a , —C(O)NR b R c , —NR b C(O)R c , —NHC(O)NHR b , or —NHSO 2 R a ;

R 5 is R 6 , nitro, halogen, cyano, C 1-4 -haloalkyl, OR d , —C(O)R d , —C(O)OR d , —OC(O)R d , —NR e R f , —NR e C(O)R d , —NHC(O)NHR e , —NHSO 2 R e , —C(O)NR e R f , —SR c , —S(O)R c , —SO 2 R c , or —SO 2 NR c NR d ;

R 6 is C 1-8 -alkyl, aryl, or heterocyclyl, wherein the R 6 C 1-8 -alkyl substituent is optionally substituted with one or more substituents selected from the group consisting of R 7 , halogen, cyano, nitro, —OR g , —C(O)R g , —C(O)OR g , —OC(O)R g , —NR h R i , —NR h C(O)R g , —NHC(O)NHR h , and —C(O)NR h R i ; and wherein the R 6 aryl or heterocyclyl substituents are optionally substituted with one or more substituents independently selected from the group consisting of C 1-8 -alkyl, aryl, heterocyclyl, halogen, cyano, nitro, C 1-4 -haloalkyl, —OR j , —C(O)R j , —C(O)OR j , —OC(O)R j , —NR k R l , —NR k C(O)R j , —NHC(O)NHR k , —NHSO 2 R j , —C(O)NR k R l , —SR j , —S(O)R j , —SO 2 R j , and —SO 2 NR k NR l ;

R 7 is cycloalkyl, aryl, heteroaryl, or heterocycloalkyl, wherein the cycloalkyl, aryl, heteroaryl, or heterocycloalkyl are optionally substituted with C 1-8 -alkyl, halogen, cyano, nitro, C 1-4 -haloalkyl, —OR j , —C(O)R j , —C(O)OR j , —OC(O)R j , —NR k R l , —NR k C(O)R j , —NHC(O)NHR k , —NHSO 2 R l , —C(O)NR k R l , —SR j , —S(O)R j , —SO 2 R j , or —SO 2 NR k NR l ,

R 8 is hydrogen, C 1-8 -alkyl, or —C(O)C 1-8 -alkyl;

R 9 is hydrogen, C 1-8 -alkyl, phenyl, or benzyl, wherein the C 1-8 -alkyl is optionally substituted with —OC 1-8 -alkyl, —C(O)C 1-8 -alkyl, —C(O)OC 1-8 -alkyl, or —OC(O)C 1-8 -alkyl, and wherein R 9 phenyl or benzyl ring is optionally substituted with —OC 1-8 -alkyl, —C(O)C 1-8 -alkyl, —C(O)OC 1-8 -alkyl, or —OC(O)C 1-8 -alkyl;

R 10 is hydrogen or C 1-8 -alkyl;

R 11 is hydrogen, C 1-8 -alkyl, —C(O)R m , —C(O)NH 2 , —C(O)NHR m , —C(O)NR m R n , or —S(O) 2 R m ;

R a , at each occurrence, is selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R b and R c , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R d , at each occurrence, is selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R e and R f , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -Cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R g , at each occurrence, is selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R h and R i , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R j , at each occurrence, is selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R k and R l , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, C 2-8 -alkenyl, C 2-8 -alkynyl, aryl, heterocyclyl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 ;

R m and R n , at each occurrence, are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, phenyl, and benzyl;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 , wherein A is thiazolyl, pyridinyl, or pyrrolyl.

3. The compound of claim 1 , wherein X is —CH 2 — or —NR 8 — and m is 1 and n is 1.

4. The compound of claim 1 , wherein R 2 is hydrogen.

5. The compound of claim 1 , wherein B is phenyl, pyridyl, tetrahydropyridyl, pyrimidinyl, pyridazinyl, pyrrolyl, imidazyl, pyrazolyl, triazolyl, furanyl, thiophenyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, oxadiazolyl, or isothiazolyl.

6. The compound according to claim 1 , wherein B is indolyl, isoindolyl, indazolyl, isoindazoyl, quinolinyl, benzoxazolyl, benzofuranyl, benzothiophenyl, benzothiazolyl, benzimidazolyl, benzotriazolyl, 1,2,3,4-tetrahydroquinoline, 1,2,3,4-tetrahydroisoquinoline, isoindolinyl, indolinyl, or pyrazolo[1,5-a]pyridine.

7. The compound according to claim 5 , wherein B is pyridinyl, tetrahydropyridinyl, pyrazolyl, or phenyl.

8. The compound of claim 1 , wherein R 3 is hydrogen.

9. The compound of claim 1 , wherein R 4a and R 4b are each independently hydrogen, hydroxy, nitro, halogen, cyano, trifluoromethyl, trifluoromethoxy, or C 1-4 -alkyl.

10. The compound of claim 9 , wherein R 4a is hydrogen and R 4b is halogen.

11. The compound of claim 1 , wherein R 1 is —OH or —NH 2 .

12. The compound of claim 1 , wherein R 1 is fluoro.

13. The compound of claim 5 , wherein B is substituted with R 5 and p is 1, wherein R 5 is C 1-8 -alkyl, wherein the C 1-8 -alkyl is optionally substituted one or two substituents independently selected from the group consisting of R 7 , —OR g , —C(O)OR g , —NR h R i , —NR h C(O)R 9 , and —C(O)NR h R i , wherein R 7 is heterocycloalkyl is optionally substituted with C 1-8 -alkyl, C 1-4 -haloalkyl, halogen, —OR j , or —NR k R l , wherein R g , R h , R i , R j , R k , and R l are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, aryl, and C 3-8 -cycloalkyl.

14. The compound of claim 5 , wherein B is substituted with R 5 and p is 1, wherein R 5 is heterocycloalkyl, wherein the heterocycloalkyl is optionally substituted with C 1-8 -alkyl, C 1-4 -haloalkyl, halogen, —OR j , or —NR k R l , wherein R j , R k , and R l are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, aryl, and C 3-8 -cycloalkyl.

15. The compound of claim 5 , wherein B is substituted with R 5 and p is 1, 2, or 3, and R 5 is selected from the group consisting of halogen, C 1-4 -haloalkyl, OR d , —C(O)OR d , —NR e C(O)R d , —NHSO 2 R e , —C(O)NR e R f , —SO 2 R c , and —SO 2 NR c NR d ; R d , R e , and R f are independently selected from the group consisting of hydrogen, C 1-8 -alkyl, aryl, and C 3-8 -cycloalkyl, wherein the C 1-8 -alkyl, aryl, and C 3-8 -cycloalkyl are optionally substituted with one or more substituents independently selected from the group consisting of aryl, heterocyclyl, C 3-8 -cycloalkyl, halogen, cyano, hydroxy, C 1-8 -alkoxy, —NH 2 , —NH(C 1-8 -alkyl), and —N(C 1-8 -alkyl) 2 .

16. The compound of claim 1 of formula (I), selected from the group consisting of

1-(5-{5-chloro-2-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-fluoro-2-(4-piperazin-1-ylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-(5-{2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

5-chloro-4-{2-[1-(methoxymethoxy)cyclobutyl]-1,3-thiazol-5-yl}-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine;

1-(5-{5-chloro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-chloro-2-(4-piperazin-1-ylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

5-chloro-4-[2-(1-methoxycyclobutyl)-1,3-thiazol-5-yl]-2-(4-piperazin-1-ylphenyl)-1H-pyrrolo[2,3-b]pyridine;

1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-fluoro-2-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-fluoro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

3-(5-{5-chloro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

3-(5-{5-chloro-2-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

1-(5-{5-chloro-2-[1-(1,3-dioxolan-2-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-(5-{5-chloro-2-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}benzoic acid;

1-{5-[5-chloro-2-(1-{2-[cyclopropyl(methyl)amino]ethyl}-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-(5-{5-chloro-2-[6-(4-methylpiperazin-1-yl)pyridin-3-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

5-chloro-4-(2-{3-[(4-methoxybenzyl)oxy]oxetan-3-yl}-1,3-thiazol-5-yl)-2-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine;

3-(5-{5-chloro-2-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

1-{5-[5-chloro-2-(5-piperidin-3-yl-1,2,4-oxadiazol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

1-(5-{5-chloro-2-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{4-[(dimethylamino)methyl]-3-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-2-fluorobenzyl)pyrrolidin-3-ol;

1-[5-(5-chloro-2-{3-fluoro-4-[(3-fluoropyrrolidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-[5-(5-chloro-2-{3-fluoro-4-[(2-methylpyrrolidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-{5-[5-chloro-2-(4-{[cyclopropyl(methyl)amino]methyl}-3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-[5-(5-chloro-2-{3-fluoro-4-[(4-fluoropiperidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-[5-(5-chloro-2-{4-[(4,4-difluoropiperidin-1-yl)methyl]-3-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-[5-(5-chloro-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-[5-(5-chloro-2-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-(5-{5-chloro-2-[4-(ethylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

3-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}benzoic acid;

(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)acetic acid;

(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-1H-pyrazol-1-yl)acetic acid;

1-(5-{5-chloro-2-[1-(2-hydroxyethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-chloro-2-(2-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-methylphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-piperidin-4-yl-1,2,4-oxadiazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-3-(pyrrolidin-1-ylmethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3-methylphenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-2-methoxyphenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

1-{5-[5-chloro-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

3-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}benzonitrile;

1-(5-{5-chloro-2-[1-(N,N-dimethylglycyl)-2,3-dihydro-1H-indol-5-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-chloro-2-(2,3-dihydro-1H-indol-5-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

3-(5-{5-fluoro-2-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)azetidin-3-ol;

1-(5-{5-chloro-2-[3-fluoro-4-(hydroxymethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[4-(2-pyrrolidin-1-ylethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{4-[(4-methyl-1,4-diazepan-1-yl)carbonyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-[5-(5-chloro-2-{4-[4-(dimethylamino)piperidin-1-yl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-{5-[5-fluoro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3-fluorophenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

N˜1˜-(3-chloro-4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-2-methylphenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

N˜1˜-(2-chloro-4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}phenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-2-fluorophenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

1-[5-(5-fluoro-2-{1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

2-(4-{5-fluoro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-1H-pyrazol-1-yl)-N-(methylsulfonyl)acetamide;

1-[5-(5-chloro-2-{1-[(1-methylpiperidin-4-yl)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

N˜1˜-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3-methoxyphenyl)-N˜2˜,N˜2˜-dimethylglycinamide;

1-(5-{5-chloro-2-[4-(tetrahydrofuran-3-yloxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[4-(tetrahydrofuran-2-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[4-(1,4-dioxan-2-ylmethoxy)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{4-[(1-methylpiperidin-4-yl)oxy]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-[5-(5-fluoro-2-{1-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxoethyl]-1H-pyrazol-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-{5-[5-chloro-2-(1,5-dimethyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-[5-(5-chloro-2-{-4-[(3,3-difluoropiperidin-1-yl)methyl]-3-fluorophenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

4-(4-{5-chloro-4-[2-(1-hydroxycyclobutyl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-2-fluorobenzyl)piperazin-2-one;

1-{5-[5-chloro-2-(4-{[3-(dimethylamino)pyrrolidin-1-yl]methyl}-3-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-fluoro-4-{[4-(trifluoromethyl)piperidin-1-yl]methyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-chloro-2-(3-fluoro-4-{[3-(trifluoromethyl)piperidin-1-yl]methyl}phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-[5-(5-chloro-2-{3-fluoro-4-[(2-methylpiperidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-(5-{5-chloro-2-[3-fluoro-4-(piperazin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-{4-[(4-fluoropiperidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-(5-{5-chloro-2-[1-(pyridin-2-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[1-(pyridin-3-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[1-(pyridin-4-ylmethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-chloro-2-pyrazolo[1,5-a]pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

3-[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]azetidin-3-ol;

1-{5-[5-chloro-2-(1,2,3,6-tetrahydropyridin-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[5-fluoro-2-(3,4,5-trimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-(5-{5-fluoro-2-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-[5-(5-fluoro-2-quinolin-6-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]cyclobutanol;

1-{5-[5-fluoro-2-(5-methoxy-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

3-[5-(5-fluoro-2-pyridin-4-yl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]azetidin-3-ol;

3-{5-[5-fluoro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}azetidin-3-ol;

3-(5-{2-[4-(ethylsulfonyl)phenyl]-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)azetidin-3-ol;

3-(5-{5-fluoro-2-[3-fluoro-4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)azetidin-3-ol;

3-[5-(5-fluoro-2-phenyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]azetidin-3-ol;

3-[5-(2-{4-[(3,3-difluoropiperidin-1-yl)methyl]phenyl}-5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]azetidin-3-ol;

3-[5-(5-fluoro-2-{4-[(2-methylpyrrolidin-1-yl)methyl]phenyl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]azetidin-3-ol;

3-[5-(5-fluoro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]-1-methylazetidin-3-ol;

1-(5-{5-chloro-2-[1-(1,4-dioxan-2-ylcarbonyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-(5-{5-chloro-2-[1-(N,N-dimethylglycyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-fluoro-2-(5-methoxy-1-methyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

1-{5-[2-(5-fluoro-1-methyl-1H-indol-3-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

3-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}oxetan-3-ol;

1-(5-{2-[3-(methylsulfonyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanol;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)-N-(4-methoxybenzyl)amine;

1-{1-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1H-pyrazol-4-yl}cyclobutanol;

5-chloro-4-[2-(1-fluorocyclobutyl)-1,3-thiazol-5-yl]-2-[1-(2-morpholin-4-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine;

5-chloro-4-[2-(1-fluorocyclobutyl)-1,3-thiazol-5-yl]-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridine;

5-chloro-4-[2-(1-fluorocyclobutyl)-1,3-thiazol-5-yl]-2-[1-(2-pyrrolidin-1-ylethyl)-1H-pyrazol-4-yl]-1H-pyrrolo[2,3-b]pyridine;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}-1-methylpyrrolidin-3-ol;

3-(5-{5-chloro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylpyrrolidin-3-ol;

1-(5-{5-fluoro-2-[2-(4-oxa-1-azabicyclo[3.2.1]oct-5-yl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol;

1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutanamine;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-0yl}cyclobutyl)acetamide;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)benzamide;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)-N′-ethylurea;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)methanesulfonamide;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}-1-methylazetidin-3-ol;

3-(5-{5-chloro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylazetidin-3-ol;

1-(1-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-4-yl)cyclobutanol;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)urea;

N′-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)-N,N-dimethylurea;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)-N,N-dimethylamine;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}-1-ethylpyrrolidin-3-ol;

1-acetyl-3-(5-{5-chloro-2-[4-(morpholin-4-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)pyrrolidin-3-ol;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}tetrahydrothiophene-3-ol 1,1-dioxide;

N-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)-N′-phenylurea;

N-benzyl-N′-(1-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}cyclobutyl)urea;

3-(5-{5-chloro-2-[3-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylpyrrolidin-3-ol;

1-{3-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,2,4-oxadiazol-5-yl}cyclobutanol;

3-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylpyrrolidin-3-ol;

3-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylazetidin-3-ol;

3-(5-{5-chloro-2-[3-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)-1-methylazetidin-3-ol;

3-[5-(5-chloro-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]-1-methylpyrrolidin-3-ol;

1-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}pyridin-2-yl)cyclobutanol;

3-{5-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-2-yl}tetrahydrothiophene-3-ol;

3-(1-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1H-pyrazol-4-yl)oxetan-3-ol;

3-(5-{5-chloro-2-[1-(N,N-dimethylglycyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

3-(5-{5-chloro-2-[1-(1-methyl-L-prolyl)-1,2,3,6-tetrahydropyridin-4-yl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)oxetan-3-ol;

2-[4-{5-chloro-4-[2-(3-hydroxyoxetan-3-yl)-1,3-thiazol-5-yl]-1H-pyrrolo[2,3-b]pyridin-2-yl}-3,6-dihydropyridin-1(2H)-yl]-N,N-dimethylacetamide;

3-[5-(5-chloro-2-{1-[(1,1-dioxidotetrahydrothien-3-yl)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]oxetan-3-ol;

3-[5-(5-chloro-2-{1-[(1-methylpyrrolidin-3-yl)carbonyl]-1,2,3,6-tetrahydropyridin-4-yl}-1H-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-2-yl]oxetan-3-ol;

3-(5-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)tetrahydrothiophene-3-ol 1,1-dioxide;

N-[3-(2-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-5-yl)oxetan-3-yl]-N′-phenylurea;

3-{2-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-5-yl}oxetan-3-amine;

N-(3-{2-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-5-yl}oxetan-3-yl)acetamide;

N-(3-{2-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-5-yl}oxetan-3-yl)-N′-phenylurea;

N-(3-{2-[5-chloro-2-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1,3-thiazol-5-yl}oxetan-3-yl)urea;

3-(2-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-5-yl)oxetan-3-amine;

N-[3-(2-{5-chloro-2-[4-(pyrrolidin-1-ylmethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-5-yl)oxetan-3-yl]acetamide;

1-(5-{5-chloro-2-[(1E)-3-pyrrolidin-1-ylprop-1-enyl]-1H-pyrrolo[2,3-b]pyridin-4-yl}-1,3-thiazol-2-yl)cyclobutanol,

or a pharmaceutically acceptable salt thereof.

17. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.