Controlled vapor deposition of biocompatible coatings for medical devices
View Patent ↗An intraocular lens with a hydrophilic polymer coating composition and method of preparing same are provided. Specifically, a composition suitable for reducing tackiness in intraocular lenses is provided wherein an acrylic intraocular lens is treated by vapor deposition with an alkoxy silyl terminated polyethylene glycol polymer composition.
1. A method for providing an intraocular lens surface with a hydrophilic polymer coating comprising:
applying at least one hydrophilic polymer coating to at least one surface of said intraocular lens using vapor deposition,
wherein the vapor deposition comprises the steps of:
a) exposing a surface of the intraocular lens to an oxygen-comprising plasma in a processing chamber which is at subatmospheric pressure;
b) subsequently, without exposure of said oxygen-comprising plasma treated surface to ambient conditions which contaminate or react with said plasma treated surface, exposing said surface to a silicon chloride containing vapor in the presence of moisture, to form a hydrophilic silicon oxide layer on said surface; and
c) subsequently, without exposure of said hydrophilic silicon oxide layer to ambient conditions which contaminate or react with said hydrophilic silicon oxide layer, exposing said silicon oxide layer to a polyethylene glycol polymer having a plurality of monomers to form a layer selected from the group consisting of a monolayer, a self-aligned monolayer, and a polymerized cross-linked layer, wherein of the monomers have a structure of Formula 1:
wherein R 1 , R 2 and R 3 can be, individually a chlorine or a methoxy group;
x is 3;
y is an integer from 6 to 9; and
R′ is a methoxy.
2. The method according to claim 1 wherein R 1 , R 2 and R 3 all comprise methoxy groups.
3. The method according to claim 1 wherein said monomer has the structure of Formula 2: