Electrode assembly for delivering a therapeutic agent into ocular tissue
View Patent ↗A contact electrode assembly for delivering at least one therapeutic agent into ocular tissue of a subject includes a flexible dielectric layer, a first electrode portion, and a second electrode portion. The flexible dielectric includes oppositely disposed first and second surfaces. The first electrode portion is disposed on the first surface of the dielectric layer. The second electrode portion is disposed on a portion of the second surface of the dielectric layer. The second electrode portion includes an interdigitated electrode having a first comb-shaped portion defining a first plurality of fingers and a second comb-shaped portion defining a second plurality of fingers. Each of the first electrode portion, the first comb-shaped portion, and the second comb-shaped portion is electrically connectable to a signal source.
1. A system for motivating at least one therapeutic agent through an ocular membrane of a subject, said system comprising:
a cover electrode member having oppositely first and second surfaces, said second surface including an electrically-conductive portion that is electrically connectable to a signal source;
a contact electrode assembly in electrical communication with said cover electrode member, said contact electrode assembly comprising:
a flexible dielectric layer having oppositely disposed first and second surfaces;
a second electrode portion disposed on said first surface of said dielectric layer;
a third electrode portion disposed on a portion of said second surface of said dielectric layer, said third electrode portion comprising an interdigitated electrode that includes:
a first comb-shaped portion defining a first plurality of fingers; and
a second comb-shaped portion defining a second plurality of fingers; and
a medicament layer including the at least one therapeutic agent, said medicament layer being disposed on a first surface of said second electrode portion;
wherein each of said first electrode portion, said second electrode portion, said first comb-shaped portion, and said second comb-shaped portion is electrically connectable to a signal source.
2. The system of claim 1 , wherein said second electrode portion comprises a plurality of ribs spaced apart from one another by a first plurality of gaps sufficient to allow an amount of the at least one therapeutic agent to pass therethrough.
3. The system of claim 1 , wherein each of said first, second, and third electrode portions is dome-shaped and adapted to conform to the contour of the ocular tissue when said system is contacted with the ocular membrane.
4. The system of claim 1 , wherein each of said first and second pluralities of fingers is spaced apart by a second plurality of gaps sufficient to allow an amount of the at least one therapeutic agent to pass therethrough.
5. The system of claim 1 , wherein the signal source is an AC signal source capable of providing an electric signal having an orienting frequency or an electrical signal having a motivating frequency, or both.
6. The system of claim 1 , wherein the ocular membrane is not mechanically disrupted by the system.
7. The system of claim 1 , wherein each of said first, second, and third electrode portions is comprised of an electrically-conductive ink.
8. The system of claim 7 , wherein each of said second and third electrode portions is printed onto said first and second surfaces of said dielectric layer, respectively.
9. A system for motivating at least one therapeutic agent through an ocular membrane of a subject, said system comprising:
a dome-shaped cover electrode member having oppositely first and second surfaces, said second surface including an electrically-conductive portion that is electrically connectable to a signal source, said electrically-conductive portion comprising an electrically-conductive ink;
a dome-shaped contact electrode assembly in electrical communication with said cover electrode member, said contact electrode assembly comprising:
a flexible, dome-shaped dielectric layer having oppositely disposed first and second surfaces;
a second electrode portion disposed on said first surface of said dielectric layer, said second electrode portion comprising an electrically-conductive ink;
a dome-shaped third electrode portion disposed on a portion of said second surface of said dielectric layer, said third electrode portion comprising an electrically-conductive ink, said third electrode portion comprising an interdigitated electrode that includes:
a first comb-shaped portion defining a first plurality of fingers; and
a second comb-shaped portion defining a second plurality of fingers; and
a medicament layer including the at least one therapeutic agent, said medicament layer being disposed on a first surface of said second electrode portion;
wherein each of said first electrode portion, said second electrode portion, said first comb-shaped portion, and said second comb-shaped portion is electrically connectable to a signal source.
10. The system of claim 9 , wherein the ocular membrane is not mechanically disrupted by the system.