IP Library Granted Patent US 8,815,775
Granted Patent B2
US 8,815,775 · App. 13/108,496 · Granted Aug 26, 2014

Bis(difluoromethyl)pyrazoles as fungicides

Inventors: Pierre Cristau (Lyons, FR); Sebastian Hoffmann (Neuss, DE); Joachim Kluth (Langenfeld, DE); Thomas Seitz (Langenfeld, DE); Tomoki Tsuchiya (Düsseldorf, DE); Pierre Wasnaire (Düsseldorf, DE); Jürgen Benting (Leichlingen, DE); Ulrike Wachendorff-Neumann (Neuwied, DE)
Assignee: Bayer CropScience AG
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Quick Facts
Patent No.
US 8,815,775
App. No.
13/108,496
Granted
Aug 26, 2014
Kind
B2
Abstract

Bis(difluoromethyl)pyrazole derivatives of the formula (I) in which the symbols R 1 , X, Y and Q are each as defined in the description, and agrochemically active salts thereof, and use thereof for controlling phytopathogenic harmful fungi, and also processes for preparing compounds of the formula (I).

Claims (41)

1. A compound of formula (I)

in which:

X is oxygen or sulphur,

R 1 is hydrogen or halogen,

Y is oxygen or sulphur,

Q is —NR 2 R 3 ,

R 2 is hydrogen, C 1 -C 3 -alkyl, C 2 -C 3 -alkenyl, C 2 -C 3 -alkynyl, C 4 -C 10 -cycloalkylalkyl, C 4 -C 10 -alkylcycloalkyl, C 5 -C 10 -alkylcycloalkylalkyl, C 1 -C 3 -haloalkyl, C 2 -C 3 -haloalkenyl, cyano, hydroxyl, C 1 -C 3 -alkoxy, C 2 -C 3 -alkoxyalkyl, C 1 -C 3 -hydroxyalkyl, C 2 -C 3 -alkylcarbonyl, C 2 -C 3 -alkoxycarbonyl, C 2 -C 3 -alkylaminocarbonyl or C 3 -C 5 -dialkylaminocarbonyl,

R 3 is an 8- to 11-membered, unsubstituted or substituted, saturated or partly saturated homo-bicyclic ring system

and agrochemically active salts thereof.

2. The compound of formula (I) according to claim 1 ,

in which:

X is oxygen,

R 1 is hydrogen or fluorine,

Y is oxygen,

Q is

Q2=

Q5=

Q8=

Q10=

Q11=

Q13=

Q14=

or Q17=

m is 0, 1 or 2,

n is 0, 1 or 2,

R 2 is hydrogen or C 1 -C 3 -alkyl,

R 6 is hydrogen, C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkyl, C 2 -C 4 -alkoxyalkyl, or C 1 -C 4 -haloalkyl,

R 7 is in each case independently hydrogen, C 1 -C 4 -alkyl, halogen, cyano, hydroxyl, amino, nitro, C 2 -C 4 -alkenyl, C 3 -C 4 -alkynyl, C 1 -C 4 -haloalkyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 2 -C 4 -alkoxyalkyl, C 1 -C 4 -alkylamino, C 2 -C 6 -dialkylamino, C 3 -C 6 -cycloalkylamino, C 2 -C 4 -alkylcarbonyl, C 2 -C 4 -alkoxycarbonyl, C 2 -C 4 -alkylaminocarbonyl, C 2 -C 4 -alkylaminocarbonyloxy, C 3 -C 6 -dialkylaminocarbonyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 2 -C 4 -alkylcarbonyloxy, C 2 -C 4 -alkylcarbonylthio, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkylthio, C 1 -C 4 -alkyl sulphinyl, C 1 -C 4 -haloalkyl sulphinyl, C 1 -C 4 -alkylsulphonyl, C 1 -C 4 -haloalkylsulphonyl, or tri(C 1 -C 2 -alkyl)silyl,

R 8 is in each case independently C 1 -C 6 -alkyl, halogen, cyano, hydroxyl, amino, nitro, C 2 -C 6 -alkenyl, C 3 -C 6 -alkynyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 2 -C 4 -alkoxyalkyl, C 1 -C 4 -alkylamino, C 2 -C 8 -dialkylamino, C 3 -C 6 -cycloalkylamino, C 2 -C 4 -alkylcarbonyl, C 2 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkylaminocarbonyl, C 3 -C 8 -dialkylaminocarbonyl, C 1 -C 4 -hydroxyalkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -haloalkoxy, C 2 -C 6 -alkylcarbonyloxy, C 2 -C 6 -alkyl carbonylthio, C 1 -C 4 -alkylthio, C 1 -C 4 -haloalkylthio, C 1 -C 4 -alkylsulphinyl, C 1 -C 4 -haloalkylsulphinyl, C 1 -C 4 -alkylsulphonyl, C 1 -C 4 -haloalkylsulphonyl, or tri(C 1 -C 2 -alkyl)silyl,

and agrochemically active salts thereof.

3. A method for controlling phytopathogenic harmful fungi comprising applying a least one compound of formula (I) according to claim 1 to the phytopathogenic harmful fungi, their habitat, or a combination thereof.

4. A composition for controlling phytopathogenic harmful fungi at least one compound of formula (I) according to claim 1 an extender, a surfactant, or a combination thereof.

5. A process for producing a composition for controlling phytopathogenic harmful fungi, said process comprising mixing at least one bis(difluoromethyl)pyrazole derivative of formula (I) according to claim 1 with an extender, a surfactant, or a combination thereof.

6. A method for treating a seed comprising applying at least one compound of formula (I) according to claim 1 to the seed in need of such treatment.

7. A method for treating a transgenic plant comprising applying at least one compound of formula (I) according to claim 1 to the transgenic plant in need of such treatment.

8. A method for treating a transgenic seed comprising applying at least one compound of formula (I) according to claim 1 to the transgenic seed in need of such treatment.

9. A method for controlling phytopathogenic harmful fungi, said method comprises applying a least one compound of formula (I) according to claim 2 to the phytopathogenic harmful fungi, their habitat, or a combination thereof.

10. A composition for controlling phytopathogenic harmful fungi comprising at least one compound of formula (I) according to claim 2 , an extender, a surfactant, or a combination thereof.

11. A process for producing a composition for controlling phytopathogenic harmful fungi, said process comprises mixing at least one bis(difluoromethyl)pyrazole derivative of formula (I) according to claim 2 with an extender, a surfactant, or a combination thereof.

12. A method for treating a seed comprising applying at least one compound of formula (I) according to claim 2 to the seed in need of such treatment.

13. A method for treating a transgenic plant comprising applying at least one compound of formula (I) according to claim 2 to the transgenic plant in need of such treatment.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 27, 2015
From: BAYER CROPSCIENCE AG
To: BAYER INTELLECTUAL PROPERTY GMBH
Reel/Frame 035051/0545 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2011
From: CRISTAU, PIERRE; HOFFMANN, SEBASTIAN; KLUTH, JOACHIM; SEITZ, THOMAS; TSUCHIYA, TOMOKI; WASNAIRE, PIERRE; BENTING, JURGEN; WACHENDORFF-NEUMANN, ULRIKE
To: BAYER CROPSCIENCE AG
Reel/Frame 026779/0262 →
Priority Claims (1)
EP 10163067 · May 18, 2010 · regional
Continuity (2)
Provisional Application 61345796 · May 18, 2010
Related Publication 20110301197A1 · Dec 8, 2011