Reduction of pain through lower fluence rates and longer treatment times
View Patent ↗A method of treating a subcutaneous fat region is provided. The method includes generating electromagnetic radiation having a wavelength of about 1,200 nm to about 1,230 nm and delivering an average power density of less than or equal to about 2.3 W/cm 2 of the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds. The method also includes cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds. The method further includes causing necrosis of at least one fat cell in the subcutaneous fat region.
1. A method of treating a subcutaneous fat region, comprising:
generating electromagnetic radiation having a non-fat selective wavelength;
delivering the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds;
cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds;
causing necrosis of at least one fat cell in the subcutaneous fat region; and
adjusting an average power density based on a thickness of skin overlying the subcutaneous fat region,
wherein delivering the electromagnetic radiation to the subcutaneous fat region comprises delivering the electromagnetic radiation in three consecutive time intervals including:
a first time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation at a first power density;
a second time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation while the electromagnetic radiation decreases from the first power density to a second power density in a continuous manner; and
a third time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation at the second power density, wherein the first time interval is shorter than the sum of the second time interval and the third time interval.
2. The method of claim 1 wherein the non-fat selective wavelength is 950 nm to 1180 nm.
3. The method of claim 1 further comprising delivering an average power density of less than or equal to 5 W/cm 2 of the electromagnetic radiation.
4. The method of claim 1 further comprising delivering the electromagnetic radiation to the subcutaneous fat region for 300 seconds to 400 seconds.
5. The method of claim 1 wherein the electromagnetic radiation comprises a plurality of pulses of electromagnetic radiation.
6. The method of claim 1 wherein the average power density is 0.5 W/cm 2 to 5 W/cm 2 .
7. The method of claim 1 wherein the peak power density exceeds 5 W/cm 2 .
8. The method of claim 1 further comprising delivering the electromagnetic radiation simultaneously to a surface of skin overlying the subcutaneous fat region, the surface of skin having an area of at least 10 cm 2 .
9. The method of claim 1 further comprising delivering the electromagnetic radiation in the absence of precooling of the epidermal region and the portion of the dermal region overlying the subcutaneous fat region.
10. The method of claim 1 further comprising damaging the at least one fat cell so that lipid contained within can escape and at least a portion of the lipid can be carried away from the subcutaneous fat region of skin.
11. The method of claim 1 further comprising delivering the electromagnetic radiation to the subcutaneous fat region greater than or equal to 3 mm below a surface of skin.
12. The method of claim 1 further comprising massaging a skin region overlying the subcutaneous fat region prior to, during or after delivery of the electromagnetic radiation.
13. The method according to claim 1 wherein the power density averaged over the first time interval is higher than the power density averaged over the second time interval.
14. The method according to claim 1 wherein a temperature of a dermal region is maintained below 44° C. the while the peak temperature within the subcutaneous fat region is maintained at at least 50° C.
15. A method of treating a subcutaneous fat region, comprising:
generating electromagnetic radiation having a non-fat selective wavelength;
delivering the electromagnetic radiation to the subcutaneous fat region for at least 300 seconds;
cooling an epidermal region and at least a portion of a dermal region overlying the subcutaneous fat region for at least a portion of the at least 300 seconds;
causing necrosis of at least one fat cell in the subcutaneous fat region; and
adjusting an average power density based on a thickness of skin overlying the subcutaneous fat region,
wherein delivering the electromagnetic radiation to the subcutaneous fat region comprises delivering the electromagnetic radiation in three consecutive time intervals including:
a first time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation at a first power density;
a second time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation while the electromagnetic radiation decreases from the first power density to a second power density; and
a third time interval during which the subcutaneous fat region is exposed to the electromagnetic radiation at the second power density, wherein the first time interval is shorter than the sum of the second time interval and the third time interval.