Clay-based hemostatic agents and devices for the delivery thereof
View Patent ↗A device for promoting the clotting of blood comprises a clay material in particle form and a receptacle for containing the clay material. At least a portion of the receptacle is defined by a mesh. Another device comprises a gauze substrate and a clay material disposed on the gauze substrate. Another device is a bandage comprising a substrate, a mesh mounted on the substrate, and particles of a clay material retained in the mesh. A hemostatic sponge comprises a substrate, a hemostatic material disposed on a first surface of the substrate, and a release agent disposed on a second surface of the substrate. The release agent is disposed on the wound-contacting surface of the substrate. When treating a bleeding wound, application of the hemostatic sponge causes at least a portion of the hemostatic material to come into contact with blood through the release agent and through the substrate.
1. A device for promoting the clotting of blood, comprising:
a dry gauze;
a clay material disposed on the gauze;
a binder, comprising a material that is distinct from the gauze and the clay, that adheres at least a portion of the clay material to a surface of the gauze so that the device is substantially free of loose clay;
wherein the device is substantially dry; and
wherein, when the device contacts a bleeding wound, the clay material is configured to directly contact blood.
2. The device of claim 1 , wherein the clay comprises kaolin.
3. The device of claim 1 , wherein the binder comprises chitosan, polyvinyl alcohol, guar gum, gelatinized starches, polysaccharides, cellulose, carboxymethylcellulose, or calcium alginate.
4. The device of claim 1 , wherein the gauze is nonwoven.
5. The device of claim 1 , wherein the gauze comprises polyester.
6. The device of claim 1 , wherein the gauze comprises rayon.
7. The device of claim 6 , wherein the gauze comprises polyester.
8. The device of claim 2 , wherein at least one of an analgesic and an anti-inflammatory agent is mixed with, associated with, or incorporated into the kaolin.
9. The device of claim 8 , wherein an analgesic is mixed with, associated with, or incorporated into the kaolin.
10. The device of claim 2 , wherein at least one of an antibiotic, an antifungal agent, an anti-microbial agent, a silver ions, and copper ions is mixed with, associated with, or incorporated into the kaolin.
11. The device of claim 1 , further comprising the clay material impregnated into the gauze.
12. The device of claim 1 , wherein kaolin is present in the device at a weight that is at least about 44% of the total weight of the gauze and the kaolin in the device.
13. The device of claim 1 , wherein the device is configured to substantially absorb blood.
14. A device for promoting the clotting of blood, comprising:
a gauze that is in a state such that it is not saturated with a liquid, and is configured so as to be capable of absorbing a substantial amount of blood;
a clay material disposed on the gauze;
a binder, comprising a material that is distinct from the gauze and the clay, that adheres at least a portion of the clay material to a surface of the gauze so that the device is substantially free of loose clay;
wherein the clay material is positioned on the device in a region configured to contact blood when the device is placed on a bleeding wound.
15. The device of claim 14 , wherein the clay comprises kaolin.
16. The device of claim 14 , wherein the binder comprises chitosan, polyvinyl alcohol, guar gum, gelatinized starches, polysaccharides, cellulose, carboxymethylcellulose, or calcium alginate.
17. The device of claim 14 , wherein the gauze is nonwoven.
18. The device of claim 14 , wherein the gauze comprises polyester.
19. The device of claim 18 , wherein the gauze comprises rayon.
20. A method of promoting the clotting of blood, comprising administering the device of claim 14 to a person suffering from a wound with a sufficient amount of bleeding so as to have substantial need for use of a such a device.