Polymer bonded redox molecules and methods of making the same
View Patent ↗A non-leaching mediator may include a polymer having a polymeric backbone, and a plurality of phenothiazine groups bonded to the polymeric backbone. The plurality of phenothiazine groups may include at least one of a phenothiazine group having the general formula (IV): and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and a phenothiazine group having the general formula (V): and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.
1. A polymer, comprising:
a polymeric backbone, and
a plurality of phenothiazine groups bonded to the polymeric backbone;
where the plurality of phenothiazine groups includes at least one of a phenothiazine group having the general formula (IV):
and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded, and
a phenothiazine group having the general formula (V):
and salts thereof, where n is about 9 and “R” represents the polymeric backbone to which the phenothiazine group is bonded.
2. The polymer of claim 1 , where the phenothiazine group is bonded to the polymeric backbone through a carbon-heteroatom bond.
3. The polymer of claim 1 , where the phenothiazine group is bonded to the polymeric backbone through a group selected from the group consisting of an ether group, an ester group, a carbonate group, a urea group, a urethane group, an amine group, an amide group, a thioether group, a thiourea group and a sulfonamide group.
4. A method of making the polymer of claim 1 , comprising:
forming the polymer from
a polymer comprising a precursor polymeric backbone and a plurality of nucleophilic side groups bonded to the precursor polymeric backbone, and
a mixture of 2-(8-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid and 2-(2-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.
5. The method of claim 4 , further comprising:
forming the mixture of 2-(8-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)-benzene-1,4-disulfonic acid and 2-(2-(ω-haloalkyl)-3H-phenothiazin-3-ylideneamino)-benzene-1,4-disulfonic acid.
6. A method of making the polymer of claim 1 , comprising:
forming the polymer from
a compound comprising a plurality of epoxide groups, and
a mixture of 2-(8-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid and 2-(2-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.
7. The method of claim 6 , further comprising:
forming the mixture of 2-(8-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid and 2-(2-(ω-(bis(ω-hydroxyalkyl)amino)alkyl)-3H-phenothiazin-3-ylideneamino)benzene-1,4-disulfonic acid.