IP Library › Granted Patent US 8,680,263
Granted Patent B2
US 8,680,263 · App. 13/119,276 · Granted Mar 25, 2014

Carbohydrate-based drug delivery polymers and conjugates thereof

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 8,680,263
App. No.
13/119,276
Granted
Mar 25, 2014
Kind
B2
Abstract

Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.

Claims (25)

1. A monofunctional water-soluble carbohydrate-based reagent having a structure selected from

where:

POLY 1 is a dextran polymer.

2. The reagent of claim 1 , wherein POLY 1 has a molecular weight of 200 Da to 2,000,000 Da.

3. The reagent of claim 1 , wherein POLY 1 has a molecular weight of 5,000 Da to 70,000 Da.

4. The reagent of claim 1 , wherein POLY 1 has a molecular weight of about 5,000 Da.

5. The reagent of claim 1 , wherein POLY 1 has a molecular weight of about 10,000 Da.

6. The reagent of claim 1 , wherein POLY 1 has a molecular weight of about 20,000 Da.

7. The reagent of claim 1 , wherein POLY 1 has a molecular weight of about 40,000 Da.

8. The reagent of claim 1 , wherein POLY 1 has a molecular weight of about 70,000 Da.

9. The reagent of claim 1 , wherein the reagent has the structure

where POLY 1 is a dextran polymer having a molecular weight of 200 Da to 2,000,000 Da.

10. The reagent of claim 9 , wherein POLY 1 has a molecular weight of 5,000 Da to 70,000 Da.

11. The reagent of claim 9 , wherein POLY 1 has a molecular weight of about 20,000 Da.

12. The reagent of claim 9 , wherein POLY 1 has a molecular weight of about 40,000 Da.

13. The reagent of claim 1 , wherein the reagent has the structure

where POLY 1 is a dextran polymer having a molecular weight of 200 Da to 2,000,000 Da.

14. The reagent of claim 13 , wherein POLY 1 has a molecular weight of 5,000 Da to 70,000 Da.

15. The reagent of claim 13 , wherein POLY 1 has a molecular weight of about 20,000 Da.

16. The reagent of claim 13 , wherein POLY 1 has a molecular weight of about 40,000 Da.

17. The reagent of claim 1 , wherein the reagent has the structure

where POLY 1 is a dextran polymer having a molecular weight of 200 Da to 2,000,000 Da.

18. The reagent of claim 17 , wherein POLY 1 has a molecular weight of 5,000 Da to 70,000 Da.

19. The reagent of claim 17 , wherein POLY 1 has a molecular weight of about 20,000 Da.

20. The reagent of claim 17 , wherein POLY 1 has a molecular weight of about 40,000 Da.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 28571, FRAME 0141 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036866/0700 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
GRANT OF SECURITY INTEREST Recorded Jul 17, 2012
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 028571/0141 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 9, 2011
From: KOZLOWSKI, ANTONI; MCMANUS, SAMUEL P.; SHEN, XIAOMING
To: NEKTAR THERAPEUTICS
Reel/Frame 026880/0152 →