Metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent
View Patent ↗A compound comprising a metal chelate linked to a hexose carrier for use as a metallopharmaceutical diagnostic or therapeutic agent is provided. The compound is suitable for imaging by single-photon emission computed tomography, computer assisted tomography, magnetic resonance spectroscopy, magnetic resonance imaging, positron emission tomography, fluorescence imaging or x-ray.
1. A metallopharmaceutical hexose derivative compound of the formula:
wherein R 8 comprises one or more metal ions.
2. The compound of claim 1 , wherein R 8 is selected from the group consisting of Lutetium, 177 Lutetium, Yttrium, 86 Yttrium, 90 Yttrium, Indium, 111 Indium, 113m Indium, Technetium, 98 Technetium, 99m Technetium, Rhenium, 186 Rhenium, 188 Rhenium, Gallium, 67 Gallium, 68 Gallium, Copper, 62 Copper, 64 Copper, 67 Copper, Gadolinium, 153 Gadolinium, Dysprosium, 169 Dysprosium, 166 Dysprosium, Holmium, 166 Holmium, Europium, 169 Europium, Samarium, 153 Samarium, Palladium, 103 Palladium, Promethium, 149 Promethium, Thulium, 170 Thulium, Bismuth, 212 Bismuth, Arsenic and 211 Arsenic.
3. The compound of claim 1 , wherein R 8 is selected from the group consisting of 68 Gallium, 177 Lutetium, 86 Yttrium, 90 Yttrium, 111 Indium, 113m Indium, 98 Technetium, 99m Technetium, 186 Rhenium and 188 Rhenium.
4. The compound of claim 1 , wherein R 8 is 111 Indium.