Pharmaceutical composition for improving intestinal absorption
View Patent ↗An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR 4 )—, —(CR 5 R 6 )— or the like; B represents an alkylene group or an alkenylene group; R 1 represents an alkyl group, an alkenyl group or the like; R 2 represents an adamantylalkyl group or the like; R 3 represents an unsaturated heterocyclic ring; R 4 , R 5 and R 6 each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.
1. A pharmaceutical composition comprising (a) 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea or a salt thereof and (b) a lipophilic substance, wherein the lipophilic substance is a propylene glycol monocaprylate.
2. The composition according to claim 1 , which further comprises a solubilizer and/or a surfactant.
3. A method for improving intestinal absorption of 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea or a salt thereof, which method comprises administering to a patient a pharmaceutical composition comprising (a) 1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea and (b) a lipophilic substance, wherein the lipophilic substance is propylene glycol monocaprylate.
4. The method according to claim 3 , wherein the pharmaceutical composition comprises a solubilizer and/or a surfactant.