Methods for treating gastrointestinal diseases
View Patent ↗Described herein are macrolide and ketolide antibiotics and pharmaceutical compositions, methods, and uses thereof for treating gastrointestinal diseases.
1. A method for treating a gastrointestinal disease caused by a bacteria in a host animal, the method comprising the step of administering to the host animal an effective amount of a compound of the formula
or pharmaceutically acceptable salt thereof;
or an antibacterial composition thereof further comprising one or more pharmaceutically acceptable carriers, excipients, or diluents therefor, or a combination thereof.
2. A method for treating a gastrointestinal disease caused by a bacteria in a host animal, the method comprising the step of administering an effective amount of the compound recited in claim 1 , or an antibacterial composition thereof further comprising one or more pharmaceutically acceptable carriers, excipients, or diluents therefor, or a combination thereof, wherein the effective amount is capable of killing the bacteria.
3. The method of claim 1 wherein the gastrointestinal disease is enteritis or gastroenteritis, or a combination thereof.
4. The method of claim 1 wherein the gastrointestinal disease is caused at least in part by an organism selected from the group consisting of Salmonella, Shigella, Staphylococcus, Campylobacter, Helicobacter, Clostridium, Escherichia coli , and Yersinia , and combinations thereof.
5. The method of claim 1 wherein the gastrointestinal disease is caused at least in part by H. pylori, C. jejuni, Salmonella, Shigella , or a combination thereof.
6. The method of claim 1 wherein the compound recited in claim 1 is of the formula
7. The method of claim 1 wherein the compound recited in claim 1 is of the formula
where HX is a pharmaceutically acceptable salt forming acid.
8. The method of claim 7 wherein HX is selected from the group consisting of hydrochloric acid, tartaric acid, and combinations thereof.