Medical implant including a 3D mesh of oxidized cellulose and a collagen sponge
The present invention relates to A bioresorbable implant comprising: a bioresorbable porous layer including a biopolymer foam and defining first pores, a bioresorbable porous three-dimensional mesh made from a microbial cellulose and defining second pores, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh. The invention also relates to a method of making a bioresorbable implant.
1. A bioresorbable implant comprising:
a bioresorbable porous layer including a biopolymer foam defining first pores, and a three-dimensional density from about 30 mg collagen/cm 3 to about 150 mg collagen cm 3 ,
a bioresorbable porous three-dimensional mesh made from a microbial cellulose having a thickness of about 0.1 cm to about 3 cm, and defining second pores from about 0.5 mm to about 5 mm, wherein the bioresorbable porous layer is disposed in the bioresorbable porous three-dimensional mesh, and
a non-porous film applied to the bioresorbable porous three-dimensional mesh including the bioresorbable porous layer.
2. The bioresorbable implant of claim 1 , wherein the first and second pores are at least partially interconnected with one another.
3. The bioresorbable implant of claim 1 , wherein the microbial cellulose is derived from Acetobacter xylinum as wet pellicles or films.
4. The bioresorbable implant of claim 1 , wherein the microbial cellulose is oxidized.
5. The bioresorbable implant of claim 1 , wherein the biopolymer foam comprises pores having a size of from about 10 μm to about 500 μm.
6. The bioresorbable implant of claim 1 , wherein the biopolymer foam is from about 0.2 to about 1.5 cm thick.
7. The bioresorbable implant of claim 1 , further comprising a bioactive agent.
8. The bioresorbable implant of claim 1 , wherein the microbial cellulose mesh displays a minimal elongation at break in at least one direction of about 50 N.
9. The bioresorbable implant of claim 1 , wherein the microbial cellulose has a thickness of about 0.2 cm to about 1 cm.
10. The bioresorbable implant of claim 1 , wherein the non-porous film is positioned on a first side of the implant to reduce postsurgical adhesions and the porous layer is positioned on a second side opposite the first side of the implant to allow for cell colonization.
11. The bioresorbable implant of claim 1 , wherein the non-porous layer is from about 30 μms to about 75 μms thick and the porous layer is from about 0.3 cms to about 1.2 cms thick.
12. A method of making a bioresorbable implant, comprising:
adding an aqueous acid solution or suspension of collagen to a bioresorbable porous three-dimensional mesh made from a microbial cellulose having a thickness of about 0.1 cm to about 3 cm, and defining second pores from about 0.5 mm to about 5 mm,
lyophilizing the solution to create a bioresorbable foam layer in the bioresorbable porous three-dimensional mesh, wherein the bioresorbable foam layer includes a three-dimensional density from about 30 mg collagen/cm 3 to about 150 mg collagen/cm 3 , and
applying a non porous layer to the bioresorbable porous three-dimensional mesh that has been filled with the bioresorbable foam layer.
13. The method of claim 12 , wherein the biopolymer foam layer is cross-linked.
14. The method of claim 12 , wherein the non porous layer comprises a collagenic constituent.
15. The method of claim 12 , wherein the microbial cellulose has a thickness of about 0.2 cm to about 1 cm.
16. The method of claim 12 , wherein the non-porous film is positioned on a first side of the implant to reduce postsurgical adhesions and the porous layer is positioned on a second side opposite the first side of the implant to allow for cell colonization.
17. The method of claim 12 , wherein the non-porous layer is from about 30 μmsto about 75 μms thick and the porous layer is from about 0.3 cms to about 1.2 cms thick.