Methods and compositions for treating complement-associated disorders
The present disclosure relates to, inter alia, compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b.
1. A method for treating atypical hemolytic uremic syndrome (aHUS), the method comprising administering to a patient in need thereof eculizumab in an amount effective to treat aHUS in the patient; wherein the eculizumab is intravenously administered to the patient under the following schedule:
at least 600 mg of eculizumab once per week for four consecutive weeks; and
beginning at week five, maintenance doses of at least 900 mg eculizumab every two weeks thereafter.
2. The method of claim 1 , wherein the eculizumab is administered to the patient in an amount and with a frequency to maintain at least 50 μg of eculizumab per milliliter of the patient's blood.
3. The method of claim 1 , wherein the eculizumab is administered to the patient in an amount and with a frequency to maintain at least 100 μg of eculizumab per milliliter of the patient's blood.
4. The method of claim 1 , wherein the eculizumab is administered to the patient in an amount and with a frequency to maintain a concentration of at least 0.7 molecules of eculizumab per every C5 molecule in the patient's blood.