Systems, materials, and processes for isolating nanoparticles
View Patent ↗Processes for isolating nanoparticles from an aqueous solution are disclosed. The processes can include, for example, providing an aqueous mixture having a plurality of nanoparticles and at least one thermal hysteresis molecule; adjusting the aqueous mixture to a temperature effective to form ice crystals within the aqueous mixture; and isolating the ice crystals from the aqueous mixture. Also disclosed are compositions and systems for isolating nanoparticles.
1. A process for isolating nanoparticles from a mixture, the process comprising:
providing an aqueous mixture comprising a plurality of nanoparticles and at least one thermal hysteresis molecule, wherein the aqueous mixture includes an amount of the plurality of nanoparticles less than or equal to about 1 g/L;
adjusting the aqueous mixture to a temperature effective to form ice crystals within the aqueous mixture without solidifying the entire aqueous mixture, wherein the ice crystals comprise at least a portion of the nanoparticles; and
isolating the ice crystals from the aqueous mixture, wherein isolating the ice crystals comprises at least one of filtering the ice crystals from the aqueous mixture or applying a centrifugal force to the aqueous mixture to isolate the ice crystals based on specific density differences between the ice crystals and liquid in the aqueous mixture.
2. The process of claim 1 , wherein the isolating step comprises separating the ice crystals based on specific density differences between the ice crystals and liquid in the aqueous mixture.
3. The process of claim 1 , wherein the isolating step comprises centrifuging the aqueous mixture.
4. The process of claim 1 , wherein the isolating step comprises filtering the ice crystals from the mixture.
5. The process of claim 4 , wherein the filtering step is configured to remove components having a size greater than about 1 μm.
6. The process of claim 1 , wherein the temperature is equal to or less than about 0° C.
7. The process of claim 1 , wherein the aqueous mixture is maintained at the temperature during the isolating step.
8. The process of claim 1 , wherein the nanoparticles comprise at least one inorganic material.
9. The process of claim 8 , wherein the inorganic material is selected from the group consisting of metals and ceramics.
10. The process of claim 8 , wherein the inorganic material comprises gold, silver, copper, cadmium, lead, selenium, mercury, or combinations thereof.
11. The process of claim 1 , wherein the thermal hysteresis molecule is present in the aqueous mixture at a concentration of at least about 1 μg/mL.
12. The process of claim 1 , wherein the aqueous mixture comprises at least about 10 ppm of nanoparticles.
13. The process of claim 1 , wherein the thermal hysteresis molecule is an antifreeze protein or an antifreeze glycoprotein.
14. The process of claim 1 , wherein the thermal hysteresis molecule is a Type I antifreeze protein.
15. The process of claim 1 , wherein the thermal hysteresis molecule is a Type II antifreeze protein.
16. The process of claim 1 , wherein the thermal hysteresis molecule is a Type III antifreeze protein.
17. The process of claim 1 , wherein the thermal hysteresis molecule is an antifreeze glycoprotein.
18. The process of claim 1 , wherein the thermal hysteresis molecule is a synthetic organic compound.
19. The process of claim 1 , wherein the thermal hysteresis molecule is a polymer.
20. The process of claim 19 , wherein the polymer is a polycarboxylic acid, a polyglycerol, a methyl acrylate-co-vinyl pyrrolidone, a methyl methacrylate-co-vinyl-pyrrolidone, polyvinyl acetate, polyvinyl alcohol, or combinations thereof.