Site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites
The teachings provided herein generally relate to site-activated binding systems that selectively increase the bioactivity of phenolic compounds at target sites. More particularly, the systems taught here include a phenolic compound bound to a reactive oxygen species, wherein the phenolic compound and the reactive oxygen species react at a target area in the presence of an oxidoreductase enzyme.
1. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising:
an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis , pomegranate, resveratrol, and combinations thereof; and,
hydrogen peroxide;
wherein,
the hydrogen peroxide is combined with the extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,
the extract comprises a flavanol.
2. A pharmaceutical formulation comprising the system of claim 1 and a pharmaceutically acceptable excipient.
3. The system of claim 1 , wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof.
4. The system of claim 1 , wherein the extract comprises a catechin.
5. The system of claim 1 , wherein the extract comprises gallic acid, epigallic acid, or a combination thereof.
6. The system of claim 1 , wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50.
7. A kit for generating the binding system of claim 1 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
8. A kit comprising the binding system of claim 1 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
9. A binding system, comprising
an extract of Chinese gall; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a flavanol.
10. The system of claim 9 comprising a catechin.
11. The system of claim 9 comprising gallic acid, epigallic acid, or a combination thereof.
12. A binding system, comprising
an extract of pomegranate; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a flavanol.
13. The system of claim 12 comprising a catechin.
14. The system of claim 12 comprising gallic acid, epigallic acid, or a combination thereof.
15. A binding system, comprising
an extract of Camilla Sinensis ; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a flavanol.
16. The system of claim 15 comprising a catechin.
17. The system of claim 15 comprising gallic acid, epigallic acid, or a combination thereof.
18. The system of claim 15 comprising an extract of pomegranate.
19. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising:
an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis , pomegranate, resveratrol, and combinations thereof; and,
hydrogen peroxide;
wherein,
the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,
the extract comprises a catechin.
20. A pharmaceutical formulation comprising the system of claim 19 and a pharmaceutically acceptable excipient.
21. The system of claim 19 , wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof.
22. The system of claim 19 , wherein the extract comprises a flavanol.
23. The system of claim 19 , wherein the extract comprises gallic acid, epigallic acid, or a combination thereof.
24. The system of claim 19 , wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50.
25. A kit for generating the binding system of claim 19 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
26. A kit comprising the binding system of claim 19 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
27. A binding system that selectively increases the bioactivity of a phenolic compounds at a target site, the system comprising:
an extract of a plant selected from the group consisting of Chinese gall, Camilla Sinensis , pomegranate, resveratrol, and combinations thereof; and,
hydrogen peroxide;
wherein,
the hydrogen peroxide is combined with the an extract at a weight ratio that ranges from about 1:1000 to about 10:1 of the an extract to the hydrogen peroxide; and,
the extract comprises a gallic acid, epigallic acid, or a combination thereof.
28. A pharmaceutical formulation comprising the system of claim 27 and a pharmaceutically acceptable excipient.
29. The system of claim 27 , wherein the extract comprises a hydrolysable tannin, a condensed tannin, or a combination thereof.
30. The system of claim 27 , wherein the extract comprises a flavanol.
31. The system of claim 27 , wherein the extract comprises a catechin.
32. The system of claim 27 , wherein the weight ratio of the extract to the hydrogen peroxide ranges from about 1:1 to about 1:50.
33. A kit for generating the binding system of claim 27 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
34. A kit comprising the binding system of claim 27 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
35. A binding system, comprising
an extract of Chinese gall; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a catechin.
36. The system of claim 35 comprising a flavanol.
37. The system of claim 35 comprising gallic acid, epigallic acid, or a combination thereof.
38. A kit for generating the binding system of claim 35 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
39. A kit comprising the binding system of claim 35 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
40. A binding system, comprising
an extract of Chinese gall; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a gallic acid, epigallic acid, or a combination thereof.
41. The system of claim 40 comprising a flavanol.
42. The system of claim 40 comprising a catechin.
43. A kit for generating the binding system of claim 40 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
44. A kit comprising the binding system of claim 40 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
45. A binding system, comprising
an extract of pomegranate; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a catechin.
46. The system of claim 45 comprising a flavanol.
47. The system of claim 45 comprising gallic acid, epigallic acid, or a combination thereof.
48. A kit for generating the binding system of claim 45 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
49. A kit comprising the binding system of claim 45 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
50. A binding system, comprising
an extract of pomegranate; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a gallic acid, epigallic acid, or a combination thereof.
51. The system of claim 50 comprising a flavanol.
52. The system of claim 50 comprising a catechin.
53. A kit for generating the binding system of claim 50 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
54. A kit comprising the binding system of claim 50 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
55. A binding system, comprising
an extract of Camilla Sinensis ; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a catechin.
56. The system of claim 55 comprising a flavanol.
57. The system of claim 55 comprising gallic acid, epigallic acid, or a combination thereof.
58. A kit for generating the binding system of claim 55 , wherein the kit comprises a dry form of the extract and a dry form of a hydrogen peroxide generating material, as well as instructions for mixing the components to create the binding system for administration and suggested dilution factors for various target sites.
59. A kit comprising the binding system of claim 55 , wherein the kit comprises a dry form of the binding system, as well as instructions for diluting the binding system for administration with suggested dilution factors for various target sites.
60. A binding system, comprising
an extract of Camilla Sinensis ; and,
hydrogen peroxide;
wherein the extract and the peroxide are combined to form a binding system; and,
the system comprises a gallic acid, epigallic acid, or a combination thereof.
61. The system of claim 60 comprising a flavanol.
62. The system of claim 60 comprising a catechin.
63. The system of claim 60 comprising an extract of pomegranate.
64. A binding system, comprising
a flavanol; and,
hydrogen peroxide;
wherein the flavanol and the peroxide are combined to form a binding system.
65. A binding system, comprising
a catechin; and,
hydrogen peroxide;
wherein the catechin and the peroxide are combined to form a binding system.
66. A binding system, comprising
a gallic acid, epigallic acid, or a combination thereof; and,
hydrogen peroxide;
wherein the gallic acid, epigallic acid, or a combination thereof and the peroxide are combined to form a binding system.