Device, system, and method including micro-patterned cell treatment array

1. A device comprising:

a quasi-planar substrate; and

two or more laterally-mobile effector molecule types at least partially embedded within the quasi-planar substrate, wherein at least two of the two or more laterally-mobile effector molecule types are sequentially placed to interact with one or more cell types;

one or more sensors configured to detect at least one aspect of an interaction between the at least one of the two or more laterally-mobile effector molecule types and the one or more cell types; and

a controller in communication with the one or more sensors, wherein the controller is configured to responsively initiate modification of at least one of the two or more laterally-mobile effector molecule types and the quasi-planar substrate, and wherein the controller is configured to responsively control the interaction between the at least one of the two or more laterally-mobile effector molecule types and the one or more cell types to initiate activation, maturation, differentiation, anergy induction, antigen loading, electroporation, or transduction in the one or more cell types.

2. The device of claim 1 , wherein at least one of the two or more effector molecule type is a ligand molecule.

3. The device of claim 1 , wherein at least one of the one or more effector molecule type is a receptor molecule.

4. The device of claim 1 , wherein at least one of the one or more effector molecule type is a cytokine.

5. The device of claim 1 , wherein the two or more laterally-mobile effector molecule types modified in response to the controller is different from the two or more laterally-mobile effector molecule types sensed interacting with the one or more cell types by the one or more sensors.

6. The device of claim 1 , wherein at least two of the two or more laterally-mobile effector molecule types are configured such that the one or more cell types interact simultaneously with the at least two of the two or more laterally-mobile effector molecule types.

7. The device of claim 1 , wherein the controller is configured to responsively add at least one of the two or more laterally-mobile effector molecule types to the quasi-planar substrate.

8. The device of claim 1 , wherein the controller is configured to responsively remove at least one of the one or more laterally-mobile effector molecule types from the quasi-planar substrate.

9. The device of claim 1 , wherein the quasi-planar substrate includes one or more discreet regions configured to include at least one of the two or more laterally-mobile effector molecule types.

10. The device of claim 1 , wherein the controller is configured to responsively move at least one of the two or more laterally-mobile effector molecule types and the one or more cell types relative to the quasi-planar substrate.

11. The device of claim 1 , wherein the controller is configured to responsively remove at least one of the one or more laterally-mobile effector molecule types and the one or more cell types from the quasi-planar substrate.

12. The device of claim 1 , wherein the quasi-planar substrate includes a liquid configured as an interface with a cell type-carrying fluid.

13. The device of claim 12 , wherein the liquid is configured to at least partially embed the two or more laterally-mobile effector molecule types on the quasi-planar substrate.

14. The device of claim 12 , wherein the quasi-planar substrate includes a membrane.

15. The device of claim 14 , wherein the membrane is bordered by a solid substrate.

16. The device of claim 14 , wherein the membrane includes a lipid bilayer.

17. The device of claim 14 , wherein the membrane includes a lipid monolayer.

18. The device of claim 14 , wherein the membrane is configured to contact a liquid or solid surface within the quasi-planar substrate.

19. The device of claim 12 , wherein the cell type-carrying fluid includes a gas or a liquid.

20. The device of claim 1 , wherein the quasi-planar substrate includes a solid surface configured to at least partially embed at least one of the two or more laterally-mobile effector molecule types.

21. The device of claim 20 , wherein the quasi-planar substrate includes a liquid at least partially surrounding the solid surface, wherein the liquid is configured to at least partially embed at least one of the two or more laterally-mobile effector molecule types within the liquid.

22. The device of claim 1 , wherein the quasi-planar substrate is configured to mobilize at least one of the two or more laterally-mobile effector molecule types in essentially two dimensions on the quasi-planar substrate.

23. The device of claim 1 , wherein the quasi-planar substrate is configured to bi-directionally mobilize at least one of the two or more laterally-mobile effector molecule types in essentially one dimension on the quasi-planar substrate.

24. The device of claim 1 , wherein the quasi-planar substrate is configured to include one or more spatially-discrete portions.

25. The device of claim 24 , wherein at least one of the one or more spatially-discrete portions includes two or more identical of the one or more laterally-mobile effector molecule type.

26. The device of claim 24 , wherein at least one of the one or more spatially-discrete portions includes two or more different of the two or more laterally-mobile effector molecule type.

27. The device of claim 24 , wherein the one or more spatially-discrete portions include one or more of array sites or channels.

28. The device of claim 24 , wherein the one or more spatially-discrete portions are connected with a fluidic interface.

29. The device of claim 28 , wherein the controller includes one or more of static connections or dynamic connections, wherein the one or more of the static connections or the dynamic connections are configured to control communication between the one or more spatially discrete portions.

30. The device of claim 1 , wherein at least one of the one or more laterally-mobile effector molecule types is configured to undergo a conformational change in response to interaction with the one or more cell types.

31. The device of claim 1 , wherein at least one of the one or more laterally-mobile effector molecule types is configured to react with one or more binding components in response to interaction with the one or more cell types.

32. The device of claim 31 , wherein the one or more binding components is laterally mobile in the substrate.

33. The device of claim 31 , wherein the one or more binding components is mobile in a liquid of the substrate.

34. The device of claim 31 , wherein the one or more binding components is a component of intracellular signaling.

35. The device of claim 31 , wherein the one or more binding components is on the one or more cell types.

36. The device of claim 1 , wherein at least one of the one or more laterally-mobile effector molecule types is configured to bind and interact with a single cell type of the one or more cell types.

37. The device of claim 36 , wherein the controller is configured to responsively modify the single cell type.

38. The device of claim 36 , wherein the sensor is configured to identify the single cell type, and the controller is configured to modify the single cell type.

39. The device of claim 1 , wherein the one or more sensors is configured to spatially detect at least one of the two or more laterally-mobile effector molecule types and at least one of the one or more cell types in one or more spatially-discrete portions of the quasi-planar substrate.

40. The device of claim 1 , wherein the controller is configured to direct motion of at least one of the two or more laterally-mobile effector molecule types toward or away from at least one of the one or more cell types.

41. The device of claim 1 , wherein the controller is configured to respond by introducing one or more components into or onto at least one of the one or more cell types.

42. The device of claim 1 , wherein the controller is configured to respond by applying fluidic force or motional force to the two or more laterally-mobile effector molecule types or the quasi-planar substrate.

43. The device of claim 42 , wherein force is transferred to the cell by one or more bound laterally-mobile effector molecule types.

44. The device of claim 1 , wherein the controller is configured to respond by applying motional force to the one or more cell types.

45. The device of claim 1 , wherein the controller is configured to respond by altering connectivity of the quasi-planar substrate.

46. The device of claim 1 , wherein the controller is configured to move at least one of the one or more cell types between one or more spatially discrete portions of the quasi-planar substrate.

47. The device of claim 1 , wherein the controller is configured to rotate at least one of the one or more cell types to a new orientation.

48. The device of claim 1 , wherein the controller is configured to rotate at least one of the one or more cell types by differential binding or release at one or more different sites on the at least one of the one or more cell types.

49. The device of claim 1 , wherein the controller is configured to expose different cell regions or cell receptors to the quasi-planar substrate.

50. The device of claim 1 , wherein the controller is configured to respond to binding of at least one of the one or more cell types at one region of the quasi-planar substrate by altering a configuration of the two or more laterally-mobile effector molecule types at a second region on the quasi-planar substrate.

51. The device of claim 1 , further comprising one or more fluid bypasses configured to receive and process at least one of the one or more cell types in one or more fluids from a vertebrate subject through the device and configured to return processed fluids through the one or more fluid bypasses into the vertebrate subject.