Use of titanium-based materials as bactericides
View Patent ↗Compositions containing metal ions bound into a titanate are described which have demonstrated an ability to suppress bacterial growth of a number of organisms associated with periodontal disease and caries.
1. A process for treating oral bacteria, said oral bacteria selected from the group consisting of Porphyromonas gingivalis, Fusobacterium nucleatum, Agregatibacter actinomycetemcomitans, Streptoccoccus mutans, Prevotella intermedia and Actinomyces naeslundii;
comprising exposing said bacteria to a pharmaceutical composition comprising a metal ion and a titanate carrier molecule bound to said metal ion, said titanate carrier molecule is selected from the group consisting of monosodium titanate, amorphous peroxotitanate, and combination thereof;
wherein said pharmaceutical composition provides an antibiotic effect on said bacteria.
2. A process for treating oral bacteria, said oral bacteria selected from the group consisting of Porphyromonas gingivalis, Fusobacterium nucleatum, Agregatibacter actinomycetemcomitans, Streptoccoccus mutans, Prevotella intermedia and Actinomyces naeslundii;
comprising exposing said bacteria to a pharmaceutical composition comprising a metal ion and a titanate carrier molecule bound to said metal ion in a concentration range from about 1 mg/L to about 25 mg/L, said titanate carrier molecule is selected from the group consisting of monosodium titanate, amorphous peroxotitanate, and combination thereof;
wherein said pharmaceutical composition provides an antibiotic effect on said bacteria.
3. A process for treating oral bacteria, said oral bacteria selected from the group consisting of Porphyromonas gingivalis, Fusobacterium nucleatum, Agregatibacter actinomycetemcomitans, Streptoccoccus mutans, Prevotella intermedia and Actinomyces naeslundii;
comprising exposing said bacteria to a pharmaceutical composition comprising a metal ion selected from a group consisting of Au(III), Pd(II), Pt(II), Pt(IV) and combinations thereof, and a titanate carrier molecule bound to, said metal ion, said titanate carrier molecule is selected from the group consisting of monosodium titanate, amorphous peroxotitanate, and combination thereof;
wherein said pharmaceutical composition provides an antibiotic effect on said bacteria.
4. The process according to claim 2 wherein said metal ion is selected from the group consisting of Au(III), Pd(II), Pt(II), Pt(IV) and combinations thereof.
5. The process according to claim 1 wherein said pharmaceutical composition is one of a mouthwash, a toothpaste, an oral rinse, or an oral gel.
6. The process according to claim 2 wherein said pharmaceutical composition is one of a mouthwash, a toothpaste, an oral rinse, or an oral gel.
7. The process according to claim 3 wherein said pharmaceutical composition is one of a mouthwash, a toothpaste, an oral rinse, or an oral gel.