Solid pharmaceutical composition comprising amlodipine and losartan
View Patent ↗The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.
1. A solid pharmaceutical composition comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone.
2. The composition of claim 1 , wherein the disintegrant is a mixture of sodium starch glycolate and crosspovidone.
3. The composition of claim 1 , wherein the disintegrant is a mixture of sodium starch glycolate and crosscarmellose sodium.
4. The composition of claim 1 , wherein the disintegrant is used in an amount ranging from about 2.5 to about 30% by weight based on the total weight of the composition.
5. The composition of claim 4 , wherein the disintegrant is used in an amount ranging from about 5 to about 15% by weight based on the total weight of the composition.
6. A method for treating cardiovascular disorders comprising administering the solid composition of claim 1 to a subject in need thereof.
7. The method of claim 6 , wherein the cardiovascular disorders are selected from the group consisting of angina pectoris, hypertension, artery vasospasm, deep vein, cardiac hypertrophy, cerebral infarct, congestive heart failure, and myocardial infarction.