Peptides derived from HMG-CoA reductase and cosmetic and/or pharmaceutical composition containing same
The present invention relates to peptides derived from human HMG-CoA reductase of general formula (I): R 1 -(AA) n -X1-Gly-Lys-X2-(AA) p -R 2 , And of sequence SEQ ID No. 1 to SEQ ID No. 10. The present invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically suitable medium. The present invention further relates to the use of this novel peptide as an active principle that activates human HMG-CoA reductase in a cosmetic composition intended to strengthen the barrier function of the skin and to stimulate epidermal differentiation. The invention further applies to a cosmetic treatment method intended to prevent and/or combat the external stresses and signs of cutaneous aging.
1. A peptide derived from human HMG-CoA reductase, wherein the peptide is one of the following sequences:
(SEQ ID NO: 1)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val-Cys-Glu,
(SEQ ID NO: 2)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val,
(SEQ ID NO: 3)
Asp-Gly-Lys-Gly-Lys-Thr,
(SEQ ID NO: 4)
Arg-Gly-Lys-Ser,
(SEQ ID NO: 5)
Arg-Gly-Lys-Ser-NH 2 ,
(SEQ ID NO: 6)
Arg-Gly-Lys-Thr,
(SEQ ID NO: 7)
Arg-Gly-Lys-Thr-NH 2 ,
(SEQ ID NO: 8)
Lys-Gly-Lys-Ser,
(SEQ ID NO: 9)
Lys-Gly-Lys-Ser-NH 2, and
(SEQ ID NO: 10)
Gly-Lys-Ser-NH 2 .
2. The peptide according to claim 1 wherein the peptide corresponds to the SEQ ID NO: 4 sequence.
3. The peptide according to claim 1 wherein the peptide corresponds to the SEQ ID NO: 5 sequence.
4. The peptide according to claim 1 , wherein the peptide is solubilized in one or more physiologically acceptable solvents selected from the group consisting of water, glycerol, ethanol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated diethylene glycol or propoxylated diethylene glycol, cyclic polyols, white petroleum jelly, vegetable oil and combinations thereof.
5. A cosmetic composition comprising at least one peptide derived from human HMG-CoA reductase, wherein the peptide is one of the following sequences:
(SEQ ID NO: 1)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val-Cys-Glu,
(SEQ ID NO: 2)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val,
(SEQ ID NO: 3)
Asp-Gly-Lys-Gly-Lys-Thr,
(SEQ ID NO: 4)
Arg-Gly-Lys-Ser,
(SEQ ID NO: 5)
Arg-Gly-Lys-Ser-NH 2 ,
(SEQ ID NO: 6)
Arg-Gly-Lys-Thr,
(SEQ ID NO: 7)
Arg-Gly-Lys-Thr-NH 2 ,
(SEQ ID NO: 8)
Lys-Gly-Lys-Ser,
(SEQ ID NO: 9)
Lys-Gly-Lys-Ser-NH 2 ,
(SEQ ID NO: 10)
Gly-Lys-Ser-NH 2 ; and
a physiologically acceptable medium;
wherein the peptide is present in the medium, as an active agent, alone or in combination with at least one other active principle agent.
6. The cosmetic composition according to claim 5 , wherein said peptide is present at a concentration of between 0.0005 and 500 ppm.
7. The cosmetic composition according to claim 6 , wherein said peptide is present at a concentration of between 0.01 and 5 ppm.
8. The cosmetic composition according to claim 5 wherein the composition is a topically administrable composition in the form of a cream, an oil in water emulsion, a water in oil emulsion, a solution, a suspension, a gel, a milk, a lotion, a stick, or a powder.
9. The cosmetic composition according to claim 5 , comprising an effective quantity of the peptide as an active agent that activates human HMG-CoA reductase.
10. A method for cosmetic treatment of skin, the method comprising:
topically applying, to skin to be treated, a composition comprising an effective quantity of a peptide derived from human HMG-CoA reductase,
wherein the peptide is one of the following sequences:
(SEQ ID NO: 1)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val-Cys-Glu,
(SEQ ID NO: 2)
Glu-Gly-Lys-Gly-Lys-Ser-Val-Val,
(SEQ ID NO: 3)
Asp-Gly-Lys-Gly-Lys-Thr,
(SEQ ID NO: 4)
Arg-Gly-Lys-Ser,
(SEQ ID NO: 5)
Arg-Gly-Lys-Ser-NH 2 ,
(SEQ ID NO: 6)
Arg-Gly-Lys-Thr,
(SEQ ID NO: 7)
Arg-Gly-Lys-Thr-NH 2 ,
(SEQ ID NO: 8)
Lys-Gly-Lys-Ser,
(SEQ ID NO: 9)
Lys-Gly-Lys-Ser-NH 2, and
(SEQ ID NO: 10)
Gly-Lys-Ser-NH 2 .
11. The method according to claim 10 , wherein the peptide is solubilized in one or more physiologically acceptable solvents selected from the group consisting of water, glycerol, ethanol, propanediol, propylene glycol, butylene glycol, dipropylene glycol, ethoxylated diethylene glycol or propoxylated diethylene glycol, cyclic polyols, white petroleum jelly, vegetable oil, and combinations thereof.
12. The method according to claim 10 , wherein the peptide is present at a concentration of between 0.0005 and 500 ppm.
13. The method according to claim 10 , wherein the peptide is present at a concentration of between 0.01 and 5 ppm.
14. The method of claim 10 , comprising strengthening the barrier function of the epidermis and stimulating epidermal differentiation by topically administering the composition.
15. The method of claim 10 , wherein the cosmetic treatment comprises treating against external stresses or cutaneous signs of aging and photo aging.
16. The method of claim 10 , wherein the cosmetic treatment comprises treating hypersensitive, irritated or reactive skin.
17. The method of claim 10 , wherein the cosmetic treatment comprises treating atopic eczema.