IP Library Patent Application 13142865
Patent Application
App. No. 13/142,865

METHOD AND APPARATUS FOR MINIMIZING THERMAL TRAUMA TO AN ORGAN DURING TISSUE ABLATION OF A DIFFERENT ORGAN

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Patent No.
US None
App. No.
13/142,865
Abstract

A method of minimizing thermal trauma during tissue ablation includes the steps of placing an ablation catheter at an ablation site on a first organ in a patient's body, providing energy to the ablation catheter to heat first organ tissue at the ablation site, providing microwave radiometry apparatus including a probe containing a microwave antenna and a radiometer responsive to the antenna output for producing a temperature signal corresponding to the thermal radiation picked up by the antenna and positioning the probe in a body passage of a second organ in the patient's body having a wall portion adjacent to the ablation site so that the microwave antenna is located at a measurement site opposite the ablation site. Using the radiometry apparatus, the temperature at depth in the second organ tissue at the measurement site is measured to provide a corresponding temperature signal, and the ablation catheter is controlled in response to the temperature signal to maintain the temperature of the second organ tissue below a predetermined value that does not result in thermal trauma to the second organ tissue. Apparatus for carrying out the method is also disclosed.

Claims (27)

1 . A method of minimizing thermal trauma during tissue ablation including the steps of

placing an ablation catheter at an ablation site on a first organ in a patient's body;

providing energy to the ablation catheter to heat first organ tissue at the ablation site;

providing microwave radiometry apparatus including a probe containing a microwave antenna and a radiometer responsive to the antenna output for producing a temperature signal corresponding to the thermal radiation picked up by the antenna;

positioning the probe in a body passage of a second organ in the patient's body having a wall portion adjacent to the ablation site so that the microwave antenna is located at a measurement site opposite the ablation site;

using the radiometry apparatus, measuring the temperature at depth in the second organ tissue at the measurement site to provide a corresponding temperature signal, and

controlling the ablation catheter in response to the temperature signal to maintain the temperature of the second organ tissue below a predetermined value that does not result in thermal trauma to the second organ tissue.

2 . The method defined in claim 1 wherein the first organ is the heart and the second organ is the esophagus.

3 . The method defined in claim 1 wherein the first organ is the urethra and the second organ is the rectum.

4 . The method defined in claim 1 wherein the ablation catheter is controlled by varying the distance between the ablation catheter and the ablation site.

5 . The method defined in claim 1 wherein the ablation catheter includes a heating element and is controlled by regulating the current applied to the heating element.

6 . The method defined in claim 1 wherein the ablation catheter includes an RF antenna and is controlled by regulating the energy supplied to the RF antenna.

7 . The method defined in claim 1 and further including the step of cooling the probe so as to cool the second organ tissue while ablating the first organ tissue.

8 . The method defined in claim 7 wherein the cooling step is accomplished by flowing a fluid through the probe and adjusting the flow rate and/or temperature of the fluid in response to said temperature signal.

9 . Apparatus for minimizing thermal trauma during tissue ablation comprising

an ablation catheter for positioning at an ablation site on a first organ in a patient's body;

a device for providing energy to the ablation catheter to heat first organ tissue at the ablation site;

microwave radiometry apparatus including a probe containing a microwave antenna and a radiometer responsive to the antenna output for producing a temperature signal corresponding to the thermal radiation picked up by the antenna, said probe being positioned in a body passage of a second organ in the patient's body having a wall portion adjacent to the ablation site so that the microwave antenna is located at a measurement site opposite the ablation site, said radiometry apparatus being adapted to measure the temperature at depth in the second organ tissue at the measurement site to provide a corresponding temperature signal, and

a controller controlling the ablation catheter in response to the temperature signal to maintain said temperature of the second organ tissue below a predetermined value that does not result in thermal trauma to the second organ tissue.

10 . The apparatus defined in claim 9 wherein the first organ is the heart and the second organ is the esophagus.

11 . The apparatus defined in claim 9 wherein the first organ is the urethra and the second organ is the rectum.

12 . The apparatus defined in claim 9 wherein the ablation catheter includes a heating element and the controller includes a device for regulating the current applied to the heating element.

13 . The apparatus defined in claim 9 wherein the ablation catheter includes an RF antenna and the controller includes a device for regulating the energy supplied to the RF antenna.

14 . The apparatus defined in claim 9 and further including

apparatus for flowing a cooling fluid through the probe, and

a control device for controlling the flow rate and/or temperature of the cooling fluid so as to cool the second organ tissue while ablating the first organ tissue.

15 . The apparatus defined in claim 9 wherein the radiometry apparatus also includes a temperature indicator responsive to the temperature signal for indicating the temperature of the second organ tissue.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Oct 11, 2018
From: ABBOTT LABORATORIES
To: EPIX THERAPEUTICS, INC., FORMERLY ADVANCED CARDIAC THERAPEUTICS, INC.
Reel/Frame 047218/0808 →
SECURITY INTEREST Recorded Jan 10, 2017
From: ADVANCED CARDIAC THERAPEUTICS, INC.
To: ABBOTT LABORATORIES
Reel/Frame 040936/0054 →
RELEASE OF SECURITY INTEREST Recorded Mar 6, 2014
From: NBGI TECHNOLOGY FUND II LP, AS COLLATERAL AGENT
To: ADVANCED CARDIAC THERAPEUTICS, INC.
Reel/Frame 032364/0437 →
SECURITY AGREEMENT Recorded Sep 30, 2011
From: ADVANCED CARDIAC THERAPEUTICS, INC.
To: NBGI TECHNOLOGY FUND II LP
Reel/Frame 026995/0487 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2011
From: LENIHAN, TIMOTHY J.
To: ADVANCED CARDIAC THERAPEUTICS INC.
Reel/Frame 026918/0279 →