Polymer shells
The present invention relates to a method for the preparation of polymer shells, preferably composed of cellulose or hemicellulose, comprising the steps of dissolving the polymer component in a first solvent, preferably an organic solvent and precipitating the polymer component by contacting the first solution with a second solvent, which second solvent has a polar character, and in which second solvent the polymer component is essentially insoluble, thereby obtaining polymer shells. Moreover, the invention refers to the polymer shells as such, having permeable and responsive properties, as well as various applications comprising such polymer shells within the fields of drug delivery, separation techniques, and inter alia filling material.
1. A method for preparing polymer shells, comprising the steps of:
(a) dissolving a polymer component in a first solvent;
(b) dissolving a core-forming substance in the solution obtained in step (a), wherein the core-forming substance comprises at least one gas, and wherein said dissolving comprises feeding said gas into the solution obtained in step (a) or pressurizing the solution obtained in step (a) with said gas, thereby dissolving the gas in the solution; and
(c) precipitating the polymer component and simultaneously forming cores from the core-forming substance by contacting the solution of step (b) with a second solution by transferring the solution of step (b) to the second solution by dripping or spraying, wherein droplets of the solution of step (b) are formed prior to contacting the second solution, wherein the second solution comprises a second solvent of a polar character and a surfactant, and wherein the polymer component is insoluble in the second solvent, thereby forming precipitated polymer shells having an outer diameter of from about 10 μm to about 10 mm around said cores when the solution obtained in step (b) is entering the second solution; and
wherein the polymer shells are substantially spherical.
2. The method according to claim 1 , characterized in that said polymer component consists essentially of a polymer selected from the group consisting of cellulose, hemicellulose, chitosan, galactoglucomannan, and derivatives thereof.
3. The method according to claim 1 , wherein the first solvent is dimethylacetamide (DMAc) or N-methyl morpholine oxide (NMMO).
4. The method according to claim 1 , wherein the second solvent is an aqueous solvent or a polar solvent.
5. The method according to claim 1 , wherein the solution of step (b) is transferred to the second solution with a spray device.
6. A method for preparing polymer shells, comprising the steps of:
(a) dissolving a polymer component in a first solvent, wherein the polymer component is selected from the group consisting of cellulose, hemicellulose, chitosan, and galactoglucomannan;
(b) dissolving a core-forming substance in the solution obtained in step (a), wherein the core-forming substance comprises at least one gas, and wherein said dissolving comprises feeding said gas into the solution obtained in step (a) or pressurizing the solution obtained in step (a) with said gas, thereby dissolving the gas in the solution; and
(c) precipitating the polymer component and simultaneously forming cores from the core-forming substance by contacting the solution of step (b) with a second solution by transferring the solution of step (b) to the second solution by dripping or spraying, wherein droplets of the solution of step (b) are formed prior to contacting the second solution, wherein the second solution comprises a second solvent of a polar character, and wherein the polymer component is insoluble in the second solvent, thereby forming precipitated polymer shells having an outer diameter of from about 10 μm to about 10 mm around said cores when the solution obtained in step (b) is entering the second solution.
7. The method according to claim 6 , wherein the polymer component is cellulose.
8. The method according to claim 6 , wherein the second solution comprises a surfactant.
9. The method according to claim 8 , wherein the polymer shells are substantially spherical.
10. The method according to claim 6 , wherein the first solvent is dimethylacetamide (DMAc) or N-methyl morpholine oxide (NMMO).
11. The method according to claim 6 , wherein the second solvent is an aqueous solvent or a polar solvent.