Enhancing biocompatibility of a medical device
View Patent ↗The present invention relates to a medical device comprising both pyrolytic carbon and an NO generator, methods of making same, and methods of using same.
1. A medical device, comprising:
a substrate having a surface; and
a biocompatible coating in contact with at least a portion of the surface of the substrate, the biocompatible coating comprising pyrolytic carbon, at least one NO generator, and a biodegradable polymer, wherein said biocompatible coating is a single layer comprising pyrolytic carbon in combination with a NO generator, wherein an in vivo increase in NO by said NO generator promotes endothelialization of said device, and wherein said biodegradable polymer is selected from the group consisting of poly(lactic-co-glycolic acid), polyglycolic acid, polylactic acid, and polycaprolactone.
2. The medical device of claim 1 , wherein the substrate is selected from the group consisting of graphite, metal and ceramic.
3. The medical device of claim 1 , wherein the NO generator comprises no more than about 5% of the total surface area of the biocompatible coating.
4. The medical device of claim 1 , wherein the biocompatible coating has a thickness of from about 0.01 to about 2000 microns.
5. The medical device of claim 1 , wherein the NO generator is selected from the group consisting of chalcogens, copper, or oxides thereof.
6. The medical device of claim 5 , wherein the NO generator is copper or copper oxide.
7. The medical device of claim 5 , wherein the chalcogen is selenium.
8. The medical device of claim 1 , wherein the medical device is selected from the group consisting of a heart valve prosthesis, an annuloplasty ring, a heart valve stent, a heart valve leaflet, a vascular stent, a urinary stent, a mechanical heart component, a pacemaker component, an electrical lead, a left ventricular assist device, and an orthopedic component.
9. The medical device of claim 8 , wherein the heart valve prosthesis is a noncollapsible heart valve prosthesis.
10. The medical device of claim 1 , wherein the biocompatible coating further includes a metal or a metalloid carbide.
11. The medical device of claim 10 , wherein the metalloid carbide is silicon carbide.
12. The medical device of claim 1 , wherein the biocompatible coating includes a plurality of NO generators.
13. The medical device of claim 1 , wherein the biocompatible coating has a thickness of from about 0.05 to about 500 microns.
14. The medical device of claim 1 , wherein the biocompatible coating has a thickness of from about 0.1 to about 100 microns.