IP Library Granted Patent US 8,306,305
Granted Patent B2
US 8,306,305 · App. 13/152,390 · Granted Nov 6, 2012

Bone segmentation

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Quick Facts
Patent No.
US 8,306,305
App. No.
13/152,390
Granted
Nov 6, 2012
Kind
B2
Abstract

A method of automatically identifying bone components in a medical image data set of voxels, the method comprising: a) applying a first set of one or more tests to accept voxels as belonging to seeds, b) applying a second set of one or more tests to accept seeds as bone seeds, and c) expanding the bone seeds into bone components by progressively identifying candidate bone voxels, adjacent to the bone seeds or to other previously identified bone voxels, as bone voxels, responsive to predetermined criteria which distinguish bone voxels from voxels of other body tissue.

Claims (15)

1. A method of automatically identifying bone voxels in a medical image data set of voxels that includes at least a portion of the large bones of the legs and at least a portion of the bones outside the legs, the method comprising:

a) identifying at least a portion of the voxels belonging to large bones of the legs by applying a first procedure to the voxels of the data set, comprising finding first connected sets of volume greater than a minimum volume, of voxels having density greater than a first minimum density;

b) identifying at least a portion of the voxels belonging to bones of the body outside the legs, by applying a second procedure to the voxels of the data set, comprising finding second connected sets of voxels having density greater than a second minimum density; and

c) excluding those voxels from the second connected sets of voxels that satisfy a criterion involving one or more of average density, uniformity of density, and thickness, thereby excluding voxels belonging to the aorta exceeding a threshold level of contrast agent;

wherein the second minimum density and the criterion are chosen so that voxels belonging to the large leg bones would also be excluded if the second procedure and the criterion were applied to them.

2. The method according to claim 1 , wherein the data set is defined with a z-coordinate where the z axis is a longitudinal axis of the body, the method also including identifying at least a portion of the voxels belonging to the knee bones by:

a) distinguishing femur voxels from lower leg bone voxels by their z-coordinates; and

b) identifying as belonging to the knee bones, voxels exceeding a threshold image density, whose z-coordinates are intermediate between the range of z-coordinates of the femur voxels and the range of z-coordinates of the lower leg bone voxels.

3. The method according to claim 1 , wherein the image data set is defined in an x-y-z Cartesian coordinate system having an x, y, and z axis where the z axis is a longitudinal axis of the body, and the x axis is a left-right axis of the body, and wherein the criterion comprises:

a) finding connected regions of voxels which have an image density exceeding an image density threshold value;

b) for each connected region, finding a range W in x-coordinate, a range H in y-coordinate, and a range D in z-coordinate, of the centers of the voxels in the region; and

c) identifying as belonging to the large leg bones a set of the connected regions for which the range W is similar in to the range H, and the range D is larger than for the other connected regions.

4. The method according to claim 3 , wherein finding connected regions of voxels comprises excluding connected regions which are less than a minimum volume, and the minimum volume and the image density threshold value of the image density are chosen so that any connected regions comprising voxels of blood vessels in the legs are excluded, but at least one connected region comprising voxels of large leg bones is not excluded.

5. The method according to claim 1 , wherein the data set is defined with a z-coordinate where the z axis is a longitudinal axis of the body, and wherein the first procedure comprises selecting voxels having image density greater than a first threshold value, such that only voxels in a central portion of each of the large bones of the legs are identified, the method also comprising identifying voxels belonging to end portions of the large bones of the legs, by selecting voxels which have image density greater than a second threshold value lower than the first threshold value, and which have their z-coordinate within a range determined by the locations of the voxels in the central portions of the large bones of the legs.

6. The method according to claim 5 , wherein the range excludes a central portion of the femur where blood vessels are close to the femur.

Assignments (4)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY (FIRST LIEN) Recorded Oct 14, 2022
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: CARESTREAM HEALTH, INC.; CARESTREAM DENTAL LLC; QUANTUM MEDICAL IMAGING, L.L.C.; TROPHY DENTAL INC.
Reel/Frame 061683/0441 →
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY (SECOND LIEN) Recorded Oct 14, 2022
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: CARESTREAM HEALTH, INC.; CARESTREAM DENTAL LLC; QUANTUM MEDICAL IMAGING, L.L.C.; TROPHY DENTAL INC.
Reel/Frame 061683/0601 →
SECOND LIEN INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 1, 2013
From: CARESTREAM HEALTH, INC.; CARESTREAM DENTAL LLC; QUANTUM MEDICAL IMAGING, L.L.C.; TROPHY DENTAL INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
Reel/Frame 030724/0154 →
AMENDED AND RESTATED INTELLECTUAL PROPERTY SECURITY AGREEMENT (FIRST LIEN) Recorded Jun 28, 2013
From: CARESTREAM HEALTH, INC.; CARESTREAM DENTAL LLC; QUANTUM MEDICAL IMAGING, L.L.C.; TROPHY DENTAL INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
Reel/Frame 030711/0648 →