Advanced endovascular clip and method of using same
The present disclosure provides an endovascular device for treating a defect in the vascular wall such as aneurysm by deploying a self expandable barrier around the aneurysm neck to block the blood flow to the aneurysm and method for implementing the endovascular device. The endovascular device also allows for delivery of certain swellable materials and bioactive materials, such as thrombogenic compounds, to the aneurysm to accelerate occlusion and healing of the aneurysm.
1. An aneurysm occlusion and healing device comprising:
(a) a distal member in an original configuration, comprised of a frame-less two-dimensional mesh of intersecting and interposed wires configured to be placed inside an aneurysm and extend across an aneurysm junction with the blood vessel to form a barrier to blood flow into the aneurysm;
(b) the mesh of the distal member is configured to adhere to inner lining of the aneurysm junction with the blood vessel, where intersected and interposed wires of the distal member form a scaffold to allow endothelium to grow on a surface of the distal member for sealing and healing of the aneurysm;
(c) a mesh-less proximal member, comprised of one or more support wires radially configured to be placed outside the aneurysm extending across an aneurysm neck and vessel wall and to press against the opposing surface of the distal member and adjacent vessel walls to maintain the tight adherence of the distal member against the neck of the aneurysm;
(d) where each of the distal and proximal members have an original configuration and a deformed configuration;
(e) wherein said deformed configurations are configured to change to said original configurations by an activating mechanism; and
(f) wherein a portion of each of said distal and proximal members are attached to a joint component.
2. The endovascular clip of claim 1 wherein at least one of the distal and proximal members comprises nitinol.
3. The endovascular clip of claim 1 wherein said activating mechanism comprises a temperature above a defined threshold.
4. The endovascular clip of claim 1 wherein said mesh further comprises a swellable material configured to expand in volume upon exposure to an activating condition.
5. The endovascular clip of claim 4 wherein said swellable material is selected from the group consisting of hydrogel, hydrogel foam, hydrophilic polymers with conjugate collagen, hydrophilic polymers without conjugated collagen, porous hydrated polyvinyl alcohol foam (PAF) gel, and any combination thereof.
6. The endovascular clip of claim 5 wherein said swellable material seals at least a portion of said interstices of the respective deformable component when the swellable material is exposed to vascular content.
7. The endovascular clip of claim 1 wherein said mesh further comprises a bioactive material configured to promote cell growth.
8. The endovascular clip of claim 7 wherein said bioactive material comprises a thrombogenic material.
9. The endovascular clip of claim 1 wherein said joint component is configured to be releasably attached to a delivery wire.
10. The endovascular clip of claim 1 wherein a portion of vascular wall at the aneurysm neck is sandwiched between a portion of said distal member and a portion of said proximal member when said distal member and proximal member are extended across the opening in the vascular wall.
11. The endovascular clip of claim 1 further comprising a radiopaque material.
12. The endovascular clip of claim 1 wherein said opening in a vascular wall comprise a neck of an aneurysm.
13. The endovascular clip of claim 1 wherein said proximal member comprises a wire.
14. The aneurysm occlusion and healing device of claim 1 , wherein the distal member further comprises one or more reinforcing wires.