Antibacterial compositions

1. A compound of formula (I), or a salt, hydrate, solvate or N-oxide thereof, wherein:

m is 0 or 1;

Q is hydrogen or cyclopropyl;

Alk is an optionally substituted, divalent C 1 -C 6 alkylene, alkenylene or alkynylene radical which may contain an ether (—O—), thioether (—S—) or amino (—NR)— link, wherein R is hydrogen, —CN or C 1 -C 3 alkyl;

X is —C(═O)NR 6 —, —S(O)NR 6 —, —C(═O)O— or —S(═O)O— wherein R 6 is hydrogen, optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, -Cyc, or —(C 1 -C 3 alkyl)-Cyc wherein Cyc is optionally substituted monocyclic carbocyclic or heterocyclic having 3-7 ring atoms;

Z is N;

R 2 is a group Q 1 -[Alk 1 ] q -Q 2 -, wherein

q is 0 or 1;

Alk 1 is an optionally substituted, divalent, straight chain or branched C 1 -C 6 alkylene, or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical which may contain or terminate in an ether (—O—), thioether (—S—) or amino (—NR)— link;

Q 2 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms;

Q 1 is hydrogen, an optional substituent, or an optionally substituted carbocyclic or heterocyclic radical having 3-7 ring atoms;

R 3 is a group Q 4 -[Alk 2 ] p -[Q 3 ] q — other than hydrogen wherein

p is 0;

q is independently 0 or 1;

Alk 2 is optionally substituted divalent C 1 -C 6 alkylene or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical;

Q 3 is an optionally substituted divalent monocyclic carbocyclic or heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic carbocyclic or heterocyclic radical having 9 or 10 ring atoms; and

Q 4 is hydrogen, an optional substituent, or optionally substituted carbocyclic or heterocyclic ring having 3-7 ring atoms.

2. A compound as claimed in claim 1 of formula (I) or a salt or N-oxide thereof:

wherein:

m is 0 or 1;

Q is hydrogen or cyclopropyl;

Alk is an optionally substituted, divalent C 1 -C 3 alkylene, C 2 -C 3 alkenylene or C 2 -C 3 alkynylene radical;

X is —C(═O)NH— or —C(═O)O—;

R 2 is a group Q 1 -[Alk l ] q -Q 2 -, wherein

q is 0 or 1;

Alk 1 is an optionally substituted, divalent, straight chain or branched C l -C 6 alkylene, or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical which may contain or terminate in an ether (—O—), thioether (—S—) or amino (—NR)— link;

Q 2 is an optionally substituted divalent monocyclic heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic heterocyclic radical having 9 or 10 ring atoms;

Q 1 is hydrogen, an optional substituent, or an optionally substituted heterocyclic radical having 3-7 ring atoms;

R is hydrogen, —CN or C 1 -C 3 alkyl;

R 3 is a group Q 4 -[Alk 2 ] p -Q 3 -other than hydrogen wherein

p is 0 or 1;

Alk 2 is optionally substituted divalent C 1 -C 6 alkylene or C 2 -C 6 alkenylene or C 2 -C 6 alkynylene radical;

Q 3 is an optionally substituted divalent monocyclic heterocyclic radical having 5 or 6 ring atoms or an optionally substituted divalent bicyclic heterocyclic radical having 9 or 10 ring atoms;

Q 4 is hydrogen, an optional substituent, or optionally substituted heterocyclic ring having 3-7 ring atoms.

3. A compound as claimed in claim 2 wherein, in the substituent R 2 , Q 2 is an optionally substituted pyridine, pyrimidine, pyrazine, pyran-2-one or pyridine-2-one ring.

4. A compound as claimed in claim 2 wherein, in the substituent R 3 , Q 3 is an optionally substituted pyridine ring, an optionally substituted pyrimidine ring or an optionally substituted pyrazine ring.

5. A compound as claimed in claim 2 wherein m is 1 and Q is hydrogen.

6. A compound as claimed in claim 2 wherein X is —C(O)NH—.

7. A compound as claimed in claim 2 wherein m is 1, Q is hydrogen, Alk is —CH 2 CH 2 —, and X is —C(O)NH—.

8. A compound as claimed in claim 2 wherein, in the substituent R 2 , Q 2 is an optionally substituted pyridine-3-yl ring, an optionally substituted pyrimidine-5-yl ring, an optionally substituted pyrazine-2-yl ring, an optionally substituted pyran-2-one-4-yl ring or an optionally substituted pyridine-2-one-4-yl ring.

9. A compound as claimed in claim 8 wherein, in the substituent R 2 , Q 1 is a group of formula —NR A R B , wherein R A and R B are independently hydrogen or a (C 1 -C 6 )alkyl, hydroxy(C 1 -C 6 )alkyl, or (C 1 -C 3 )alkoxy(C 1 -C 3 )alkyl group.

10. A compound as claimed in claim 8 wherein, in the substituent R 2 , Q 1 is a group of formula —NR A R B , wherein R A and R B taken together with that nitrogen form a cyclic amino ring.

11. A compound as claimed in claim 10 wherein the cyclic amino ring is a morpholinyl, piperidinyl, or piperazinyl ring.

12. A compound as claimed in claim 2 wherein, in the substituent R 2 , q is 1 and Alk 1 is an optionally substituted divalent C l -C 3 alkylene radical.

13. A compound as claimed in claim 2 wherein, in the substituent R 3 , p is 1.

14. A compound as claimed in claim 13 wherein, in the substituent R 3 , Alk 2 is an optionally substituted divalent C l -C 3 alkylene radical.

15. A compound as claimed in claim 2 wherein, in the substituent R 3 , Q 4 is hydrogen and p is 0.

16. A compound as claimed in claim 2 wherein, in the substituent R 3 , Q 3 is an optionally substituted pyridine-2-yl ring, an optionally substituted pyrimidine-2-yl ring or an optionally substituted pyrazine-2-yl ring.

17. A compound as claimed in claim 2 selected from the group consisting of:

1-(4,6-Dipyridin-3-yl-thiazolo[5,4-c]pyridin-2-yl)-3-ethyl-urea and

1-(4,6-Dipyrazin-2-yl)thiazolo[5,4-c]pyridin-2-yl)-3-ethyl-urea.

18. An antibacterial composition comprising a compound as claimed in claim 1 , together with one or more pharmaceutically acceptable carriers and/or excipients.