Topical anti-pruritic compositions and methods of action of same
View Patent ↗Topical anti-pruritic compositions and methods of using the same to treat pruritus. These anti-pruritic compositions are capable of temporarily or permanently reducing, inhibiting, treating, ameliorating, and/or preventing pruritic skin conditions, as well as other related skin conditions. In a particular aspect, the present formulations provide a quicker and more effective treatment of pruritus than do certain present pruritus-treating compositions.
1. A method for treating pruritus in a patient comprising administering to a patient suffering from pruritus a first topical composition that is a lotion consisting essentially of pramoxine or a pharmaceutically acceptable salt thereof in an amount from about 0.1 to about 5% by weight,
at least one occlusive skin conditioning agent in an amount from about 1 to about 10% by weight,
an organosiloxane in an amount from about 0.5 to about 5% by weight,
an emulsifier in an amount from about 0.5 to about 10% by weight,
a gelling agent selected from the group consisting of gum arabic, gum tragacanth, locust beam gum, guar gum, xanthan gum, and carbomer, in an amount of about 0.1 to about 2% by weight,
an emollient in an amount of about 0.01 to about 5% by weight,
and an aqueous solvent in an amount from about 60 to about 90% by weight, wherein the administration of said first composition provides a more effective treatment of said pruritus in comparison to treatment of pruritus achieved by administration of a second topical composition comprising about 1% by weight hydrocortisone.
2. The method of claim 1 , wherein said occlusive skin conditioning agent is petrolatum.
3. The method of claim 1 , wherein said emollient has the following structural formula:
wherein R 1 can be a C 7 -C 20 straight or branched alkane, C 7 -C 20 straight or branched alkene, C 7 -C 20 straight or branched alkyne, C 7 -C 20 straight or branched alkanol, C 7 -C 20 straight or branched alkenol, C 7 -C 20 straight or branched alkynol, C 7 -C 20 straight or branched ester, and C 7 -C 20 straight or branched ether; and
wherein R 2 can be a C 1 -C 8 straight or branched alkane, C 1 -C 8 straight or branched alkanol, C 1 -C 8 straight or branched ether, C 3 -C 8 cyclic hydrocarbon optionally substituted with at least one R 3 , C 3 -C 8 aromatic hydrocarbon optionally substituted with at least one R 3 , and C 3 -C 8 aryl optionally substituted with at least one R 3 ;
wherein R 3 can be a C 1 -C 8 straight or branched alkane, C 1 -C 8 straight or branched alkene, C 1 -C 8 straight or branched alkyne, C 1 -C 8 straight or branched alkanol, C 1 -C 8 straight or branched alkenol, C 1 -C 8 straight or branched alkynol, C 1 -C 8 straight or branched ester, and C 1 -C 8 straight or branched ether.
4. The method of claim 1 , wherein said topical anti-pruritic composition begins reducing symptoms of pruritus exhibited by said patient within about 15 minutes.
5. The method of claim 4 , wherein said topical anti-pruritic composition begins reducing symptoms of pruritus exhibited by said patient within about 2 minutes.
6. The method of claim 1 , wherein said topical anti-pruritic composition alleviates said pruritus within about 4 hours.
7. The method of claim 6 , wherein said topical anti-pruritic composition alleviates said pruritus within about 1 hour.
8. The method of claim 3 , wherein said emollient is isopropyl myristate.