Microfluidic device and microfluidic system with the same
View Patent ↗Provided is a microfluidic device and microfluidic system with the device. The microfluidic device includes a substrate; a channel formed in the substrate and in which a fluid can move; a valve controlling flow of a fluid flowing along the channel and including a phase transition material which can be melted by energy such as electromagnetic wave energy; and a lens disposed on the substrate and adjusting an irradiating region of the valve, onto which the energy is applied.
1. A microfluidic device comprising:
a substrate comprising an upper plate and a lower place, the upper plate and the lower plate being bonded to each other;
a channel formed in the substrate and in which a fluid can move;
a valve controlling flow of a fluid flowing along the channel and comprising a phase transition material which is in a non-fluidic phase at an ambient temperature and changes into a fluid phase upon application of energy;
a valve chamber for housing the valve, the chamber being fluid connected to the channel, wherein the valve moves from the valve chamber to the channel when the valve in the valve chamber is in fluid phase;
a first lens disposed on the substrate and adjusts a beam of the energy applied from an energy source to the valve in the channel; and
a second lens disposed on the substrate between the energy source and the valve chamber,
wherein the first lens is formed as an integral part of the upper plate or the lower plate and located on the exterior surface of the upper plate or the lower plate.
2. The microfluidic device of claim 1 , wherein the valve is located in the channel to close the channel, and, wherein the valve is melted to open the channel, when the energy beam is applied to the valve.
3. The microfluidic device of claim 1 , wherein the second lenses are detachably attached to a surface of the substrate or is integrally formed on the substrate.
4. The microfluidic device of claim 1 , wherein the first lens concentrates the beam of the energy applied from the energy source to the valve located in the channel.
5. The microfluidic device of claim 3 , wherein the second lens diverges the beam of the energy applied from the energy source to the valve.
6. The microfluidic device of claim 1 , wherein the valve comprises a plurality of minute heating particles that are dispersed in the phase transition material and each absorb the energy to emit heat.
7. The microfluidic device of claim 6 , wherein the minute heating particles are mixed with the phase transition material in a state in which the minute heating particles are dispersed in hydrophobic carrier oil.
8. The microfluidic device of claim 6 , wherein each of the minute heating particles is a minute metal oxide particle.
9. The microfluidic device of claim 8 , wherein the minute metal oxide particle comprises at least one selected from the group consisting of Al 2 O 3 , TiO 2 , Ta 2 O 3 , Fe 2 O 3 , Fe 3 O 4 and HfO 2 .
10. The microfluidic device of claim 6 , wherein each of the minute heating particles is a polymer particle, a quantum dot or a magnetic bead.
11. The microfluidic device of claim 1 , wherein the phase transition material is wax, gel or thermoplastic resin.
12. The microfluidic device of claim 11 , wherein the wax is at least one selected from the group consisting of paraffin wax, microcrystalline wax, synthetic wax and natural wax.
13. The microfluidic device of claim 11 , wherein the gel is at least one selected from the group consisting of polyacrylamide, polyacrylates, polymethacrylates and polyvinylamides.
14. The microfluidic device of claim 11 , wherein the thermoplastic resin is at least one selected from the group consisting of cyclic olefin copolymer (COC), polymethylmethacrylate (PMMA), polycarbonate (PC), polystyrene (PS), polyoxymethylene (POM), perfluoralkoxy (PFA), polyvinylchloride (PVC), polypropylene (PP), polyethylene terephthalate (PET), polyetheretherketone (PEEK), polyamide (PA), polysulfone (PSU) and polyvinylidene fluoride (PVDF).
15. The microfluidic device of claim 1 , further comprising a chamber which is formed in the substrate and houses a fluid.
16. A microfluidic system comprising:
a microfluidic device comprising:
a substrate comprising an upper plate and a lower plate bonded to each other;
a channel formed in the substrate and in which a fluid can move;
a valve controlling flow of a fluid flowing along the channel and comprising a phase transition material which is in a non-fluidic phase at an ambient temperature and changes into a fluid phase upon application of energy; and
a valve chamber for housing the valve, the chamber being fluid connected to the channel, wherein the valve moves from the valve chamber to the channel when the valve in the valve chamber is in fluid phase;
a first lens disposed on the substrate and adjusts a beam of the energy applied from an energy source to the valve in the channel; and
a second lens disposed on the substrate between the energy source and the valve chamber,
wherein the first lens is formed as an integral part of the upper plate or the lower plate and located on the exterior surface of the upper plate or the lower plate, and
an energy source disposed with a distance from the substrate and applies energy to the valve.
17. The microfluidic system of claim 16 , wherein the energy source comprises a laser light source emitting laser light.
18. The microfluidic system of claim 16 , further comprising a motor rotating the substrate in order to apply a fluid driving pressure based on a centrifugal force to the substrate.