Nucleic acid molecules encoding rage fusion proteins
View Patent ↗Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin C H 2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
1. An isolated DNA molecule having the sequence as set forth in SEQ ID NO: 54.
2. An isolated DNA molecule having the sequence as set forth in SEQ ID NO: 55.
3. An expression vector comprising the sequence as set forth in SEQ ID NO: 54.
4. An expression vector comprising the sequence as set forth in SEQ ID NO: 55.
5. A cell transfected with an expression vector of claim 3 or claim 4 .