Compositions and methods for stimulation MAGP-1 to improve the appearance of skin
View Patent ↗The present disclosure relates to methods for treating, preventing and improving the condition and aesthetic appearance of skin, particularly, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, by application of one or a combination of natural compounds or extracts that stimulate MAGP-1 expression and which improves the appearance of aged and/or photodamaged skin. The compositions of the invention are topically applied to the skin, or are delivered by directed means to a site in need thereof in an amount effective to improve the condition and aesthetic appearance of skin.
1. A composition comprising a compound having the structure of formula (I):
in a cosmetically or dermatologically acceptable vehicle.
2. The composition according to claim 1 , wherein the compound is present in an amount of from about 0.01 wt % to about 10 wt % of the total weight of the composition.
3. The composition according to claim 2 , wherein said vehicle is in the form of an emulsion comprising an emulsifier in an amount from about 0.1% to about 30% by weight.
4. The composition according to claim 3 , wherein said emulsion comprises a water-in-oil, oil-in-water, water-in-silicone, or silicone-in-water emulsion.
5. The composition according to claim 1 , wherein said composition is in the form of a lotion or cream.
6. The composition according to claim 1 , wherein said vehicle comprises one or more of glycerin, C 1-4 alcohol, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, laminar lipid materials, and silicone oils.
7. The composition according to claim 1 , wherein said vehicle comprises one or more of fatty esters, vegetable oils, and silicone oils.