Bag for a circuit of a biological liquid treatment installation
View Patent ↗The invention concerns a bag comprising a first conduit ( 13 J), a second conduit ( 13 K), the first section ( 13 J 1 ) of the first conduit ( 13 J) and the first section ( 13 K 1 ) of the second conduit ( 13 K) being opposite; a third conduit ( 13 L) linking said first respective ends ( 13 J 2, 13 K 2 ) of said first respective sections ( 13 J 1, 13 K 1 ); a fourth conduit ( 13 M) linking said second respective ends ( 13 J 3, 13 K 3 ) of said first respective sections ( 13 J 1, 13 K 1 ); a fifth conduit ( 13 N) linking both said second end ( 13 J 3 ) of said first section ( 13 J 1 ) and said first end ( 13 M 1 ) of said fourth conduit ( 13 M), and said fifth conduit ( 13 N) linking both said first end ( 13 K 2 ) and said second end ( 13 L 2 ) of said third conduit ( 13 L); said first conduit ( 13 J) and said second conduit ( 13 K) each being connected to a chromatography column connector ( 11 M).
1. A bag for a circuit of an installation for treatment of a biological liquid by chromatography, comprising:
a plurality of connectors ( 11 A- 11 R) and a network ( 12 ) for conveying liquid between said connectors ( 11 A- 11 R), said conveying network ( 12 ) being formed by a plurality of conduits ( 13 A- 13 Q); and
two flexible films ( 65 , 66 ) fastened to each other, said conduits ( 13 A- 13 Q) being formed between the two said flexible films ( 65 , 66 );
wherein a first conduit ( 13 J) is provided with a first section ( 13 J 1 ), which has a first end ( 13 J 2 ) and a second end ( 13 J 3 ) which is an opposite end to the first end ( 13 J 1 );
wherein a second conduit ( 13 K) is provided with a first section ( 13 K 1 ), which has a first end ( 13 K 2 ) and a second end ( 13 K 3 ) which is an opposite end to the first end ( 13 K 2 ), the first section ( 13 J 1 ) of the first conduit ( 13 J) and the first section ( 13 K 1 ) of the second conduit ( 13 K) being opposite;
wherein a third conduit ( 13 L) has a first end ( 13 L 1 ) and a second end ( 13 L 2 ) which is an opposite end to the first end ( 13 L 1 ), which third conduit ( 13 L) links said respective first ends ( 13 J 2 , 13 K 2 ) of said respective first sections ( 13 J 1 , 13 K 1 ) of said first conduit ( 13 J) and said second conduit ( 13 K) respectively by its first end ( 13 L 1 ) and its second end ( 13 L 2 );
wherein a fourth conduit ( 13 M) has a first end ( 13 M 1 ) and a second end ( 13 M 2 ) which is an opposite end to the first end ( 13 M 1 ), which fourth conduit ( 13 M) links said respective second ends ( 13 J 3 , 13 K 3 ) of said respective first sections ( 13 J 1 , 13 K 1 ) of said first conduit ( 13 J) and said second conduit ( 13 K) respectively by its first end ( 13 M 1 ) and its second end ( 13 M 2 );
wherein a fifth conduit ( 13 N) has a first end ( 13 N 1 ) and a second end ( 13 N 2 ) which is an opposite end to the first end ( 13 N 1 ), said fifth conduit ( 13 N) linking both the second end ( 13 J 3 ) of said first section ( 13 J 1 ) of said first conduit ( 13 J) and said first end ( 13 M 1 ) of said fourth conduit ( 13 M) by its first end ( 13 N 1 ), and said fifth conduit ( 13 N) linking both said first end ( 13 K 2 ) of said first section ( 13 K 1 ) of said second conduit ( 13 K) and said second end ( 13 L 2 ) of said third conduit ( 13 L) by its second end ( 13 N 2 ); and
said first conduit ( 13 J) being connected to a chromatography column connector ( 11 L) by said first end ( 13 J 2 ) of its first section ( 13 J 1 ), and said second conduit ( 13 K) being connected to a chromatography column connector ( 11 M) by said second end ( 13 K 3 ) of its first section ( 13 K 1 );
whereby the bag is configured such that the liquid to treat passes into said chromatography column via one of said first ( 13 J) and second ( 13 K), conduits, exits via the other of said first ( 13 J) and second ( 13 K) conduits, and the liquid to treat may avoid said chromatography column by passing into said fifth conduit ( 13 N).
2. A bag according to claim 1 , further comprising a sixth conduit ( 13 A) between a feed pump connector ( 11 A) and a waste container connector ( 11 B).
3. A bag according to claim 2 , further comprising a seventh conduit ( 13 D) which extends from a bubble trap connector ( 11 D) until it enters said sixth conduit ( 13 A).
4. A bag according to claim 3 , further comprising an eighth conduit ( 13 C) which extends from a feed pump connector ( 11 C) until it enters said seventh conduit ( 13 D).
5. A bag according to claim 4 , further comprising at least a ninth conduit ( 13 E) which extends between a bubble trap connector ( 11 E) and an instrumentation connector ( 11 H).
6. A bag according to claim 5 , further comprising at least a tenth conduit ( 13 H, 13 I) which extends from a filter connector ( 11 I, 11 J) until it enters said ninth conduit ( 13 E).
7. A bag according to claim 6 , further comprising an eleventh conduit ( 13 F) which extends between a bubble trap connector ( 11 G) and an air connector ( 11 F).
8. A bag according to claim 1 , wherein said first end ( 13 K 2 ) of said first section ( 13 K 1 ) of said second conduit ( 13 K) is connected to at least one fraction container connector ( 11 N-Q).
9. A bag according to claim 7 , further comprising a twelfth conduit ( 13 B) which extends from a waste container connector ( 11 R) until it enters said second conduit ( 13 K).
10. A bag according to claim 1 , wherein said second end ( 13 J 3 ) of said first section ( 13 J 1 ) of said first conduit ( 13 J) is connected to an instrumentation connector ( 11 K).
11. A device for an installation for biological liquid treatment by chromatography, comprising a circuit ( 8 ) comprising:
a bag ( 10 ) provided with a plurality of connectors ( 11 A- 11 R) and a network ( 12 ) for conveying liquid between said connectors ( 11 A- 11 R), said conveying network ( 12 ) being formed by a plurality of conduits ( 13 A- 13 Q), the bag ( 10 ) further comprising two flexible films ( 65 , 66 ) fastened to each other, said conduits ( 13 A- 13 Q) being formed between said two flexible films ( 65 , 66 );
a press ( 9 ) comprising a first shell ( 16 ) and a second shell ( 17 ) mounted on said first shell ( 16 ), said first shell ( 16 ) and second shell ( 17 ) cooperating with said bag ( 10 ) to form the conduits ( 13 A- 13 B) of said conveying network ( 12 ) between said flexible films ( 65 , 66 ), by clamping said bag ( 10 ) between said first shell ( 16 ) and said second shell ( 17 ); and
a plurality of valves ( 125 A-W);
wherein a first conduit ( 13 J) is provided with a first section ( 13 J 1 ), which has a first end ( 13 J 2 ) and a second end ( 13 J 3 ) which is an opposite end to the first end ( 13 J 1 );
wherein a second conduit ( 13 K) is provided with a first section ( 13 K 1 ), which has a first end ( 13 K 2 ) and a second end ( 13 K 3 ) which is an opposite end to the first end ( 13 K 2 ), the first section ( 13 J 1 ) of the first conduit ( 13 J) and the first section ( 13 K 1 ) of the second conduit ( 13 K) being opposite;
wherein a third conduit ( 13 L) has a first end ( 13 L 1 ) and a second end ( 13 L 2 ) which is an opposite end to the first end ( 13 L 1 ), which third conduit ( 13 L) links said respective first ends ( 13 J 2 , 13 K 2 ) of said respective first sections ( 13 J 1 , 13 K 1 ) of said first conduit ( 13 J) and said second conduit ( 13 K) respectively by its first end ( 13 L 1 ) and its second end ( 13 L 2 );
wherein a fourth conduit ( 13 M) has a first end ( 13 M 1 ) and a second end ( 13 M 2 ) which is an opposite end to the first end ( 13 M 1 ), which fourth conduit ( 13 M) links said respective second ends ( 13 J 3 , 13 K 3 ) of said respective first sections ( 13 J 1 , 13 K 1 ) of said first conduit ( 13 J) and said second conduit ( 13 K) respectively by its first end ( 13 M 1 ) and its second end ( 13 M 2 );
wherein a fifth conduit ( 13 N) has a first end ( 13 N 1 ) and a second end ( 13 N 2 ) which is an opposite end to the first end ( 13 N 1 ), said fifth conduit ( 13 N) linking both said second end ( 13 J 3 ) of said first section ( 13 J 1 ) of said first conduit ( 13 J) and said first end ( 13 M 1 ) of said fourth conduit ( 13 M) by its first end ( 13 N 1 ), and said fifth conduit ( 13 N) linking both said first end ( 13 K 2 ) of said first section ( 13 K 1 ) of said second conduit ( 13 K) and said second end ( 13 L 2 ) of said third conduit ( 13 L) by its second end ( 13 N 2 ); and
said first conduit ( 13 J) being connected to a chromatography column connector ( 11 L) by said first end ( 13 J 2 ) of its first section ( 13 J 1 ), and said second conduit ( 13 K) being connected to a chromatography column connector ( 11 M) by said second end ( 13 K 3 ) of its first section ( 13 K 1 ); and
wherein a first valve ( 125 L) is situated on said first section ( 13 J 1 ) of said first conduit ( 13 J), a second valve ( 125 N) is situated on said first section ( 13 K 1 ) of said second conduit ( 13 K), a third valve ( 125 P) is situated on said third conduit ( 13 L), a fourth valve ( 125 R) is situated on said fourth conduit ( 13 M), and a fifth valve ( 125 Q) is situated on said fifth conduit ( 13 N).
12. A device according to claim 11 , further comprising a sixth valve ( 125 M) situated on said first conduit ( 13 J) between said first end ( 13 J 2 ) of its first section ( 13 J 1 ) and said chromatography column connector ( 11 L).
13. A device according to claim 12 , further comprising a seventh valve ( 1250 ) situated on said second conduit ( 13 K) between said second end ( 13 K 3 ) of its first section ( 13 K 1 ) and said chromatography column connector ( 11 M).
14. A device according to claim 13 , wherein the bag ( 10 ) comprises a sixth conduit ( 13 A) between a feed pump connector ( 11 A) and a waste container connector ( 11 B), and the device comprises at least an eighth valve ( 125 A, 125 B) situated on said sixth conduit ( 13 A).
15. A device according to claim 14 , wherein said bag ( 10 ) comprises a seventh conduit ( 13 D) which extends from a bubble trap connector ( 11 D) until it enters said sixth conduit ( 13 A), and the device comprises a ninth valve ( 125 D) situated on said seventh conduit ( 13 D).
16. A device according to claim 15 , wherein said bag ( 10 ) comprises an eighth conduit ( 13 C) which extends from a feed pump connector ( 11 C) until it enters said seventh conduit ( 13 D), and the device comprises a tenth valve ( 125 C) situated on said eighth conduit ( 13 C).
17. A device according to claim 16 , wherein said bag ( 10 ) comprises a ninth conduit ( 13 E) which extends between a bubble trap connector ( 11 E) and an instrumentation connector ( 11 H), and the device comprises at least an eleventh valve ( 125 E, 125 H, 125 I) situated on said ninth conduit ( 13 E).
18. A device according to claim 17 , wherein said bag ( 10 ) comprises at least a tenth conduit ( 13 H, 13 I) which extends from a filter connector ( 11 I, 11 J) until it enters said ninth conduit ( 13 E), and the device comprises at least a twelfth valve ( 125 J, 125 K) situated on said at least a tenth conduit ( 13 H, 13 I).
19. A device according to claim 18 , wherein said bag ( 10 ) comprises an eleventh conduit ( 13 F) which extends between a bubble trap connector ( 11 G) and an air connector ( 11 F), and the device comprises at least a thirteenth valve ( 125 F) situated on said eleventh conduit ( 13 F).
20. A device according to claim 19 , wherein said first end ( 13 K 2 ) of said first section ( 13 K 1 ) of said second conduit ( 13 K) is connected to at least one fraction container connector ( 11 N-Q), and the device comprises a fourteenth valve ( 125 W) situated on said second conduit ( 13 K).
21. A device according to claim 20 , wherein said bag ( 10 ) comprises a twelfth conduit ( 13 B) which extends from a waste container connector ( 11 R) until it enters said second conduit ( 13 K), and the device comprises a fifteenth valve ( 125 V) situated on said twelfth conduit ( 13 B).
22. A device according to claim 17 , further comprising a pressure sensor ( 126 ) situated on said ninth conduit ( 13 E).