4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use
View Patent ↗Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
1. A method of treating or managing irritable bowel syndrome, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein R 4 is lower alkyl.
2. A method of treating or managing Crohn's disease, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen or lower alkyl.
3. The method of claim 2 , wherein R 4 is hydrogen.
4. The method of claim 2 , wherein R 4 is lower alkyl.
5. The method of claim 4 , wherein R 4 is ethyl.
6. A method of treating or managing ulcerative colitis, which comprises administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein R 4 is hydrogen or lower alkyl
7. The method of claim 6 , wherein R 4 is hydrogen.
8. The method of claim 6 , wherein R 4 is lower alkyl.
9. The method of claim 8 , wherein R 4 is ethyl.