IP Library › Patent Application 13164117
Patent Application
App. No. 13/164,117

PROCESS FOR OBTAINING A CONCENTRATE OF VON WILLEBRAND FACTOR OF A COMPLEX OF FACTOR VIII/VON WILLEBRAND FACTOR AND USE OF THE SAME

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Patent No.
US None
App. No.
13/164,117
Abstract

A method of treating a patient suffering from Haemophilia A and/or Von Willebrand's disease involves administering the patient a concentrate of Von Willebrand Factor (VWF) or a complex of Factor VIII/VWF prepared by creating a solution of VWF or a complex of Factor VIII/VWF containing VWF at a concentration of up to 12 IU VWF:RCo/ml and a VWF/Factor VIII ratio of 0.4 or more, and nanofiltering that starting solution through a filter of pore size of about 35 nm or smaller. The resulting VWF retains high molecular weight multimers.

Claims (5)

1 . A method of treating a patient suffering from Haemophilia A and/or Von Willebrand's disease, comprising:

Administering to said patient a therapeutically effective amount of a Von Willebrand composition prepared by:

a) creating a composition containing Von Willebrand Factor or a complex of Factor VIII/Von Willebrand Factor that contains Von Willebrand Factor in a concentration of up to 12 IU VWF:RCo/ml and a Von Willebrand Factor/Factor VIII ratio of 0.4 or more; and

b) nanofiltering the composition of step a) through a filter of pore size of about 35 nm or smaller;

wherein the product of step b) has a Von Willebrand Factor/Factor VIII ratio 0.4 or greater.