Prodrugs of 2,4-pyrimidinediamine compounds and their uses
View Patent ↗The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.
1. A method for treating rheumatoid arthritis in a subject, comprising administering to the subject an effective amount of a compound according to the formula
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound or the pharmaceutically acceptable salt thereof is in the form of a hydrate.
3. The method of claim 2 , wherein the compound is a free acid.
4. The method of claim 2 , wherein the compound is a pharmaceutically acceptable salt.
5. The method of claim 4 , wherein the pharmaceutically acceptable salt is an alkali metal salt.
6. The method of claim 5 , wherein the pharmaceutically acceptable salt is a sodium salt.
7. The method of claim 6 , wherein the pharmaceutically acceptable salt is a disodium salt.
8. The method of claim 4 , wherein the pharmaceutically acceptable salt is an alkaline earth metal salt.
9. The method of claim 8 , wherein the pharmaceutically acceptable salt is a calcium salt.