P2X7 ANTAGONISTS TO TREAT AFFECTIVE DISORDERS
The present invention provides methods to treat mood disorders and anxiety disorders using antagonists of the P2X 7 receptor and pharmaceutical compositions thereof, or combinations.
1 . A method of treating a mood disorder comprising administering a therapeutically effective amount of a modulator of P2X 7 receptor activity to a subject suffering from said mood disorder.
2 . The method of claim 1 wherein the mood disorder is selected from the group consisting of depressive, bipolar disorder, mood disorder due to a general medical condition, and substance-induced mood disorder.
3 . The method of claim 2 wherein the mood disorder is a depressive disorder, wherein the depressive disorder is selected from the group consisting of major depressive disorder and dysthymic disorder.
4 . The method of claim 1 wherein the mood disorder is a bipolar disorder, wherein the bipolar disorder is selected from the group consisting of bipolar I disorder, bipolar TT disorder and cyclothymic disorder.
5 . The method of claim 1 wherein the mood disorder is selected from the group consisting of mood disorder due to a general medical condition, and substance-induced mood disorder.
6 - 7 . (canceled)
8 . The method of claim 1 wherein the modulator of P2X 7 receptor activity is an antagonist.
9 - 11 . (canceled)
12 . A method of treating a mood disorder comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a modulator of P2X 7 receptor activity or a pharmaceutically acceptable salt thereof to a subject suffering from said mood disorder, wherein the mood disorders are selected from the group consisting of depressive, bipolar disorder, mood disorder due to a general medical condition, and substance-induced mood disorder.
13 . A method of treating anxiety disorder comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a modulator of P2X 7 , receptor activity or a pharmaceutically acceptable salt thereof to a subject suffering from said anxiety disorder, wherein the anxiety disorders are selected from the group consisting of panic attack, agoraphobia, specific phobia, social phobia, obsessive-compulsive disorder, posttraumatic stress disorder, acute stress disorder, and generalized anxiety disorder.
14 . A method for treating a patient suffering from, or susceptible to treatment resistant mood disorders comprising administering to said patient an effective amount of a first component which is a P2X 7 antagonist or a pharmaceutically acceptable salt thereof, in combination with an effective amount of a second component which is a known antidepressant or a pharmaceutically acceptable salt thereof.
15 . (canceled)