IP Library › Granted Patent US 9,274,130
Granted Patent B2
US 9,274,130 · App. 13/182,644 · Granted Mar 1, 2016

Prevention and treatment of pain using antibodies to lysophosphatidic acid

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Quick Facts
Patent No.
US 9,274,130
App. No.
13/182,644
Granted
Mar 1, 2016
Kind
B2
Abstract

Methods for preventing or treating pain are provided. Such methods comprise administering to a subject (e.g., a human subject) an antibody or antibody fragment that binds LPA. The antibody may be a humanized monoclonal antibody.

Claims (4)

1. A method of reducing neuropathic pain or pain associated with chemotherapy, comprising administering to a subject having neuropathic pain or pain associated with chemotherapy, an antibody or antibody fragment that binds and neutralizes lysophosphatidic acid, thereby reducing said neuropathic pain or pain associated with chemotherapy.

2. A method according to claim 1 wherein the antibody or antibody fragment is a monoclonal antibody or monoclonal antibody fragment.

3. A method according to claim 2 wherein the antibody or antibody fragment is a humanized monoclonal antibody or antibody fragment of a humanized monoclonal antibody.

4. A method according to claim 1 wherein the subject is a human subject.

Assignments (6)
TERMINATION AND RELEASE OF INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Apr 5, 2023
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC.; APOLLO ENDOSURGERY INTERNATIONAL, LLC; LPATH THERAPEUTICS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 063264/0046 →
SECURITY INTEREST Recorded Dec 23, 2021
From: APOLLO ENDOSURGERY, INC.; APOLLO ENDOSURGERY US, INC. (F/K/A LPATH, INC.)
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 058980/0199 →
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS Recorded Mar 18, 2019
From: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 048622/0358 →
CHANGE OF NAME Recorded Mar 27, 2017
From: LPATH, INC.
To: APOLLO ENDOSURGERY, INC.
Reel/Frame 042097/0896 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Dec 30, 2016
From: APOLLO ENDOSURGERY, INC.
To: ATHYRIUM OPPORTUNITIES II ACQUISITION LP, AS ADMINISTRATIVE AGENT
Reel/Frame 041224/0766 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 22, 2013
From: SABBADINI, ROGER A.; MATTEO, ROSALIA
To: LPATH, INC.
Reel/Frame 030851/0280 →