IP Library Granted Patent US 8,361,028
Granted Patent B2
US 8,361,028 · App. 13/184,479 · Granted Jan 29, 2013

Drug delivery device

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Quick Facts
Patent No.
US 8,361,028
App. No.
13/184,479
Granted
Jan 29, 2013
Kind
B2
Abstract

A drug delivery device having a housing containing a gas generator controlled by an electronic controller. The gas generator generates gas into a reciprocable chamber, whereby reciprocation of the chamber causes a lever to reciprocate a pawl, and this action causes a ratchet to undergo incremental advancement. The device may also be provided with manual control for delivering a bolus dose of drug when necessary.

Claims (9)

1. A drug delivery device comprising:

(a) a housing containing a drug reservoir;

(b) a slidable piston operable to expel drug from the drug reservoir;

(c) a ratchet mechanism in communication with the piston, the mechanism being operable to undergo incremental advancement and thereby to drive the drug from the reservoir in a series of fixed increments;

(d) a member operatively associated with the mechanism to cause the incremental advancement of the mechanism as the member moves in a first direction; and

(e) a gas generator located within the housing and operable to generate gas to expand a chamber, the member being in transmission relation to the chamber, whereby the member is driven by the movement of the chamber to advance the mechanism and thereby drive the drug from the reservoir in the series of fixed increments, each of the fixed increments corresponding to a respective advancement of the mechanism;

wherein the ratchet mechanism comprises a flexible ratchet element which is sufficiently stiff to drive medicament from the chamber when driven by the member and having a degree of flexibility allowing at least a portion of the ratchet element to be bent, whereby the overall length of the device is reduced relative to a device in which a rigid ratchet element protrudes linearly from the mechanism before use.

2. The drug delivery device according to claim 1 , wherein the mechanism comprises two or more co-operating flexible ratchet elements which are individually sufficiently flexible to be bent, wherein when the ratchet elements are joined the elements are together sufficiently stiff to drive medicament from the chamber when driven by the member.

3. The drug delivery device according to claim 2 , wherein the two or more co-operating flexible ratchet elements are bent away from one another over at least a portion of the ratchet mechanism not engaged with the member.

Assignments (8)
RELEASE OF PATENT SECURITY AGREEMENT (FIRST LIEN) Recorded Dec 24, 2024
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 069771/0548 →
RELEASE BY SECURED PARTY (SECOND LIEN) Recorded Oct 12, 2012
From: MORGAN STANLEY SENIOR FUNDING, INC.
To: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
Reel/Frame 029116/0379 →
NOTICE OF CHANGE IN REGISTERED OFFICE ADDRESS Recorded Sep 4, 2012
From: EDT PHARMA HOLDINGS
To: EDT PHARMA HOLDINGS
Reel/Frame 028904/0206 →
CHANGE OF NAME Recorded Sep 4, 2012
From: EDT PHARMA HOLDINGS LIMITED
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 028904/0223 →
NOTICE OF CHANGE IN REGISTERED OFFICE ADDRESS Recorded Sep 4, 2012
From: ALKERMES PHARMA IRELAND LIMITED
To: ALKERMES PHARMA IRELAND LIMITED
Reel/Frame 028904/0244 →
ASSET TRANSFER AGREEMENT Recorded Sep 4, 2012
From: ELAN PHARMA INTERNATIONAL LIMITED
To: EDT PHARMA HOLDINGS LIMITED
Reel/Frame 028904/0163 →
PATENT SECURITY AGREEMENT (FIRST LIEN) Recorded Sep 29, 2011
From: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 026994/0186 →
PATENT SECURITY AGREEMENT (SECOND LIEN) Recorded Sep 29, 2011
From: ALKERMES, INC.; ALKERMES PHARMA IRELAND LIMITED; ALKERMES CONTROLLED THERAPEUTICS INC.
To: MORGAN STANLEY SENIOR FUNDING, INC.
Reel/Frame 026994/0245 →