Contact lens care system with peroxide
View Patent ↗A contact lens disinfection system that includes a peroxide disinfection solution in combination with a lens closure. The disinfection solution comprises 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and an amino buffer component. The closure includes securing elements to position and maintain a pair of contact lenses in the disinfection solution, and a peroxide neutralization catalyst comprising platinum. In combination with the closure, the disinfection solution exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization from 12 minutes to 30 minutes in the lens closure.
1. A contact lens disinfection system comprising:
a peroxide disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and an amino buffer component at a concentration from 0.04 wt. % to 0.3 wt. %, wherein the amino buffer component is 2-amino-2-hydroxymethyl-1,3-propane diol;
in combination with a lens closure comprising securing elements to position and maintain a pair of contact lenses in the disinfection solution, and a peroxide neutralization catalyst comprising platinum,
wherein the amino buffer component is present at an effective concentration such that the disinfection system exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization from 12 minutes to 30 minutes in the lens closure.
2. A contact lens disinfection system comprising:
a peroxide disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and an amino buffer component at a concentration from 0.04 wt. % to 0.3 wt. %, wherein the amino buffer component is 2-amino-2-hydroxymethyl-1,3-propane diol;
in combination with a lens closure comprising securing elements to position and maintain a pair of contact lenses in the disinfection solution, and a peroxide neutralization catalyst comprising platinum;
wherein the amino buffer component is present at an effective concentration such that the disinfection system exhibits greater biocidal efficacy against Candida albicans or Serratia marcescens by 0.5 log-kill or greater after six hours than an equivalent contact lens disinfection solution in the absence of the amino buffer component, wherein the increase in effectiveness against Candida albicans or Serratia marcescens is provided by a delay in peroxide neutralization of the solution.
3. The lens disinfection system of claim 1 wherein the pseudo first-order, half-life of hydrogen peroxide over the initial sixty minutes is from 14 minutes to 22 minutes, and the concentration of hydrogen peroxide after an initial six hours of neutralization is less than 150 ppm.
4. The lens disinfection system of claim 1 wherein the disinfection solution further comprises an amino acid or a compound derived from an amino acid.
5. The lens disinfection system of claim 4 wherein the amino acid is selected from the group consisting of methionine, aspargine, glutamine, histidine, lysine, arginine, glycine, serine, cystine and threonine.
6. The lens disinfection system of claim 4 wherein the amino acid is present in the disinfection solution from 0.05 wt. % to 0.4 wt. %.
7. The lens disinfection system of claim 1 wherein the disinfection solution further comprises a low foam surfactant, particularly a polyoxyethylene-polyoxypropylene condensation polymer selected from the group consisting of Pluronic® L42, Pluronic® L43, Pluronic® L61, Pluronic® L81, Pluronic® 31R1, Pluronic® 31R2, Pluronic® 25R1, Pluronic® 17R1, Pluronic® 17R2, Pluronic® 12R3 and Pluronic® 17R4.
8. The lens disinfection system of claim 1 wherein the disinfection system exhibits a hydrogen peroxide neutralization profile that is more effective against Candida albicans by 0.8 log-kill or greater after six hours than an equivalent contact lens disinfection solution in the absence of the amino buffer component.
9. A contact lens disinfection system comprising:
a peroxide disinfection solution comprising 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and an amino buffer component, wherein the amino buffer component is 2-amino-2-hydroxymethyl-1,3-propane diol;
in combination with a lens closure comprising securing elements to position and maintain a pair of contact lenses in the disinfection solution, and a peroxide neutralization catalyst comprising platinum,
wherein the amino buffer component is present at a concentration of from 0.01 wt. % to 0.3 wt. % and the disinfection system exhibits a pseudo first-order, half-life of hydrogen peroxide over an initial sixty minutes of neutralization from 12 minutes to 30 minutes in the lens closure.
10. The lens disinfection system of claim 9 wherein the pseudo first-order, half-life of hydrogen peroxide over the initial sixty minutes is from 14 minutes to 22 minutes, and the concentration of hydrogen peroxide after an initial six hours of neutralization is less than 150 ppm.
11. The lens disinfection system of claim 9 wherein the disinfection system exhibits greater biocidal efficacy against Candida albicans or Serratia marcescens by 0.5 log-kill or greater after six hours than an equivalent contact lens disinfection solution in the absence of the amino buffer component, wherein the increase in effectiveness against Candida albicans or Serratia marcescens is provided by a delay in peroxide neutralization of the solution.
12. The disinfection system of claim 11 wherein the disinfection system exhibits a hydrogen peroxide neutralization profile that is more effective against Candida albicans by 0.8 log-kill or greater after six hours than the equivalent contact lens disinfection solution.
13. The disinfection system of claim 9 wherein the disinfection solution further comprises an amino acid or a compound derived from an amino acid.
14. The disinfection system of claim 9 wherein the molar ratio of hydrogen peroxide to the amino buffer component is from 10:1 to 200:1.