Mixed amino acid/mineral compounds having improved solubility
View Patent ↗Mixed amino acid/mineral compounds can include at least two amino acids bound to a central mineral atom. The combination of amino acids can be tailored to provide improved solubility, absorption, and/or bioavailability of the mineral. Optionally, organic acids can be bound to the mineral or combined with the chelate in order to further improve solubility, absorption, and/or bioavailability. Compositions including one or more mixed amino acid/mineral compounds can be included in therapeutic regimens for indications in which the mineral may treat and/or prevent a condition or symptom.
1. A composition comprising: a mineral; a first selected amino acid chelated to the mineral; and a second selected amino acid chelated to the mineral, wherein the first amino acid is different from the second amino acid the molar ratio of the first amino acid and the second amino acid is from about 1:0.2 to about 1:7, and the solubility of the composition is in the range of from about 1.5 M to about 7.5 M.
2. The composition of claim 1 , wherein the first amino acid and second amino acid are independently selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine.
3. The composition of claim 2 , wherein the first amino acid is aspartic acid.
4. The composition of claim 1 , wherein the mineral is selected from the group consisting of calcium, magnesium, manganese, iron, copper, zinc, potassium, cobalt, chromium, molybdenum, vanadium, sodium, phosphorus, lithium, rubidium cesium, francium, and selenium.
5. The composition of claim 4 , wherein the mineral is iron (II).
6. The composition of claim 5 , wherein the first amino acid is aspartic acid and the second amino acid is glycine.
7. The composition of claim 1 , further comprising at least one organic acid.
8. The composition of claim 7 , wherein the organic acid is selected from the group consisting of ascorbic acid, malic acid, fumaric acid, citric acid, lactic acid, benzoic acid, tartaric acid, adipic acid, succinic acid, acetic acid, phosphoric acid, propionic acid, maleic acid, pimelic acid, and sulfuric acid.
9. The composition of claim 8 , wherein the organic acid is malic acid or succinic acid or a combination thereof.
10. The composition of claim 7 , comprising two organic acids.
11. A composition comprising a first organic acid or salt derivative thereof and a mixed amino acid/mineral chelate comprised of a mineral; a first selected amino acid chelated to the mineral; and a second selected amino acid chelated to the mineral, wherein the first amino acid is different from the second amino acid, the molar ratio of the first amino acid and the second amino acid is from about 1:0.2 to about 1:7, and the solubility of the composition is in the range of from about 1.5 M to about 7.5 M.
12. The composition of claim 11 , wherein the first amino acid and second amino acid are independently selected from the group consisting of alanine, arginine, asparagine, aspartic acid, cysteine, cystine, glutamine, glutamic acid, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, ornithine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine.
13. The composition of claim 11 , further comprising a second organic acid or a salt derivative thereof.
14. The composition of claim 13 , wherein the first and second organic acids are independently selected from the group consisting of ascorbic acid, malic acid, fumaric acid, citric acid, lactic acid, benzoic acid, tartaric acid, adipic acid, succinic acid, acetic acid, phosphoric acid, propionic acid, maleic acid, pimelic acid, and sulfuric acid.
15. The composition of claim 14 , wherein one of the first organic acid and second organic acid is succinic acid, or malic acid, or a salt derivate thereof.
16. The composition of claim 15 , wherein one of the first organic acid and second organic acid is a succinate salt, the succinate salt being present in an effective amount for increasing absorption of the mixed amino acid mineral chelate.
17. The composition of claim 15 , wherein one of the first organic acid and second organic acid is a malate salt, the malate salt being present in an effective amount for increasing the solubility of the mixed amino acid/mineral chelate.
18. The composition of claim 11 , wherein the mineral is selected from the group consisting of calcium, magnesium, manganese, iron, copper, zinc, potassium, cobalt, chromium, molybdenum, vanadium, sodium, phosphorus, lithium, rubidium, cesium, francium, and selenium.
19. The composition of claim 18 , wherein the mineral is iron (II).
20. The composition of claim 13 , wherein the first organic acid and second organic acid are present in a molar ratio of about 1:0.1 to about 1:10.
21. The composition of claim 11 , wherein ratio of amino acid to mineral ratio is about 1:1 to about 1:10.
22. The composition of claim 11 , wherein the first organic acid is a salt derivative and the weight ratio of the mineral and the salt derivative of the first organic acid is about 1:0.1 to about 1:25.
23. The composition of claim 11 , further comprising at least one free amino acid.
24. The composition of claim 11 , which is substantially carbohydrate-free.
25. The composition of claim 11 , further comprising at least one additive selected from the group consisting of flavoring agent, nutritional agents, mineral agents, active pharmaceutical agents, and absorption promoting agents.