Method for transdermal delivery of permeant substances
View Patent ↗A method for delivering permeant substances transdermally into a membrane of an animal includes forming at least one delivery opening in the skin tissue, with the at least one delivery opening having a mean opening depth of between about 40 and about 90 microns.
1. A method for delivering permeant substances through a biological membrane of an animal comprising forming a plurality of delivery openings in the membrane, wherein an opening depth of the majority of said delivery openings falls within the range between 40 and 90 microns, and delivering a permeant through the plurality of delivery openings by placing a patch comprising the permeant over the plurality of delivery openings,
wherein the plurality of delivery openings are formed by microporation conducted with positive pressure being present between a microporator and said membrane, wherein said positive pressure results from a vacuum of about 0.25 to about 0.80 bar being applied between said microporator and said membrane.
2. The method of claim 1 wherein the opening depth of a majority of said delivery openings falls within the range of 50 to 70 microns.
3. The method of claim 2 wherein 75% of said delivery openings have an opening depth falling within the range of 50 to 70 microns.
4. The method of claim 3 wherein 75% of said delivery openings have an opening depth falling within the range of 55 microns to 65 microns.
5. The method of claim 1 wherein said delivery openings have a range of opening depths falling within one standard deviation of 50 microns to 70 microns.
6. The method of claim 5 wherein said delivery openings have a range of opening depths falling within one standard deviation of 60 microns.
7. The method of claim 1 wherein said delivery openings have a range of opening depths falling within one standard deviation of 90 microns.
8. The method of claim 1 wherein the plurality of delivery openings are formed by a planar array microporation device.
9. The method of claim 1 wherein the plurality of delivery openings are formed by a microporator selected from the group consisting of a heated probe element capable of conductively delivering thermal energy via direct contact to a biological membrane to cause the ablation of some portion of the membrane deep enough to form a micropore, the heated probe comprising an electrically heated resistive element capable of ablating a biological membrane or an optically heated topical dye/absorber layer, electro-mechanical actuator, a microlancet, an array of microneedles (solid or hollow), microprojections, microcstructures or lancets, a sonic energy ablator, a laser ablation system, and a high pressure fluid jet puncturer.
10. A method for delivering drugs transdermally into a biological membrane of an animal comprising forming a plurality of delivery openings through a membrane, wherein said delivery openings have a distribution resulting in a bell-shaped curve with said delivery openings having a mean opening depth of between 40 and 90 microns, and delivering a drug through the plurality of delivery openings by placing a patch comprising the drug over the plurality of delivery openings,
wherein the plurality of delivery openings are formed by microporation conducted with positive pressure being present between a microporator and said membrane, wherein said positive pressure results from a vacuum of about 0.25 to about 0.80 bar being applied between said microporator and said membrane.
11. The method of claim 1 wherein said positive pressure results from a vacuum of about 0.50 bar being applied between said device and said membrane.
12. The method of claim 10 wherein said positive pressure results from a vacuum of about 0.50 bar being applied between said device and said membrane.