IP Library › Granted Patent US 8,658,205
Granted Patent B2
US 8,658,205 · App. 13/195,734 · Granted Feb 25, 2014

Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

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Quick Facts
Patent No.
US 8,658,205
App. No.
13/195,734
Granted
Feb 25, 2014
Kind
B2
Abstract

The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.

Claims (7)

1. A composition comprising

1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL;

sodium chloride;

glycerin, present in an amount of about 0.1 mL/mL;

propylene glycol, present in an amount of about 0.1 mL/mL;

water, and

perfluoropropane.

Assignments (10)
RELEASE OF SECURITY INTEREST Recorded Jun 27, 2019
From: JPMORGAN CHASE BANK, N.A.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 049623/0123 →
RELEASE OF SECURITY INTEREST IN CERTAIN PATENTS Recorded Mar 30, 2017
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: LANTHEUS HOLDINGS, INC.; LANTHEUS MEDICAL IMAGING, INC.; LANTHEUS MI REAL ESTATE, LLC
Reel/Frame 042115/0715 →
NOTICE OF SUCCESSION OF AGENCY Recorded Mar 30, 2017
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 042115/0769 →
SECURITY AGREEMENT Recorded Jun 30, 2015
From: LANTHEUS MEDICAL IMAGING, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 036013/0516 →
AMENDMENT NUMBER ONE TO GRANT OF A SECURITY INTEREST - PATENTS Recorded Jul 3, 2013
From: LANTHEUS MI INTERMEDIATE, INC.; LANTHEUS MEDICAL IMAGING, INC.; LANTHEUS MI REAL ESTATE, LLC
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 030747/0814 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2011
From: HUI, POH K; BISHOP, JOHN E; MADRIGAL, ELEODORO S, JR.
To: DUPONT PHARMACEUTICALS COMPANY
Reel/Frame 027251/0625 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 18, 2011
From: BRISTOL-MYERS SQUIBB PHARMA COMPANY
To: ACP LANTERN ACQUISITION, INC.
Reel/Frame 027251/0654 →
CHANGE OF NAME Recorded Nov 18, 2011
From: DUPONT PHARMACEUTICAL COMPANY
To: BRISTOL-MYERS SQUIBB PHARMA COMPANY
Reel/Frame 027251/0738 →
CHANGE OF NAME Recorded Nov 18, 2011
From: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
To: LANTHEUS MEDICAL IMAGING, INC.
Reel/Frame 027251/0919 →
MERGER Recorded Nov 18, 2011
From: ACP LANTERN ACQUISITION, INC.
To: BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC.
Reel/Frame 027251/0994 →