Compounds, formulations and methods for reducing skin wrinkles, creasing and sagging

1. A method of reducing skin sagging, creasing and/or wrinkling, the method comprising topically administering to the sagging, creasing, and/or wrinkling skin of a person in need of treatment a composition comprising brimonidine or a pharmaceutically acceptable salt thereof, in an amount effective for amelioration of skin sagging, creasing and/or wrinkling.

2. A method of reducing skin sagging, creasing and/or wrinkling, the method comprising topically administering to the sagging, creasing, and/or wrinkling skin of a person in need of treatment the compounds shown below:

wherein each of R 1 , R 2 , and R 3 is independently hydrogen, halogen, alkyl, or alkoxy; each of R 4 and R 5 is independently hydrogen, alkyl, or alkoxy; and each of R 6 and R 7 is independently hydrogen, nitro, alkyl, or alkoxy.

3. The method according to claim 1 , wherein the composition further comprises at least one pharmaceutically acceptable carrier.

4. The method according to claim 3 , wherein the composition is of a form selected from the group consisting of a spray, a mist, an aerosol, a lotion, a gel, a cream, an ointment, a foam, a paste, an unguent, an emulsion, a liposomal suspension, a colloid and a combination thereof.

5. The method according to claim 3 , wherein the composition further comprises a cosmetic, a foundation, a moisturizer and a sun-blocking agent.

6. The method according to claim 1 , wherein the amount of composition applied to the affected area ranges from about 0.1 g/cm 2 to about 5 g/cm 2 of skin surface area.

7. The method according to claim 1 , wherein the composition further comprises at least one second active ingredient selected from the group consisting of azelaic acid, benzoyl peroxide, isotretinoin, an antibiotic, a chemically modified antibiotic, a pharmaceutically acceptable salt thereof and a combination thereof, in an amount effective for amelioration of skin sagging, creasing and/or wrinkling.

8. The method according to claim 7 , wherein the antibiotic is selected from the group consisting of clindamycin, doxycycline, erythromycin, metronidazole, sulfacetamide, and tetracycline.

9. The method according to claim 1 , further comprising systemically administering an antibiotic in an amount effective for treatment of skin sagging, creasing and/or wrinkling.

10. The method according to claim 9 , wherein the antibiotic is selected from the group consisting of clindamycin, doxycycline, erythromycin, metronidazole, sulfacetamide, and tetracycline.

11. The method according to claim 1 , wherein an amount effective for amelioration of skin sagging, creasing and/or wrinkling is an amount which ameliorates skin sagging, creasing and/or wrinkling within about 5 minutes after the administering.

12. The method according to claim 1 , wherein an amount effective for amelioration of skin sagging, creasing and/or wrinkling is an amount which ameliorates skin sagging, creasing and/or wrinkling for at least about 8 hours.

13. The method according to claim 12 , wherein an amount effective for amelioration of skin sagging, creasing and/or wrinkling is an amount which ameliorates skin sagging, creasing and/or wrinkling for up to about 12 hours.

14. The method according to claim 12 , wherein an amount effective for amelioration of skin sagging, creasing and/or wrinkling is an amount which ameliorates skin sagging, creasing and/or wrinkling for up to about 18 hours.

15. The method according to claim 12 , wherein an amount effective for amelioration of skin sagging, creasing and/or wrinkling is an amount which ameliorates skin sagging, creasing and/or wrinkling for up to about 24 hours.