Econazole composition and methods of treatment therewith
View Patent ↗The invention provides a water-based composition for treating an infection by a dermatophyte fungus comprising econazole or a pharmaceutically acceptable salt thereof. Also provided are methods of treatment utilizing the water-based foam composition, as well as its preparation.
1. An aerosol canister consisting of:
0.5-1.5% by weight econazole nitrate;
6-8% by weight of stearic acid substantially in an ionized form;
0.9-2.9% by weight of povidone;
6-9% by weight of humectants, the humectants being one or both of propylene glycol and glycerol;
0.5%-2.0% by weight of dimethicone;
2-3% by weight triethanolamine;
1-4% by weight polysorbate 20; and
water; and
one or more propellants;
wherein the composition as a pH in the range of 6-9; and
wherein the weight % of the above ingredients are provided exclusive of the one or more propellants present in the composition.
2. The aerosol canister of claim 1 consisting of:
1.0% by weight econazole nitrate;
8.0% by weight of stearic acid;
1.9% by weight of povidone;
5.8% by weight propylene glycol;
1.7% by weight glycerol;
0.95% by weight of dimethicone;
2.6% by weight triethanolamine;
3.7% by weight polysorbate 20;
water; and
one or more propellants.