Medical devices having activated surfaces
View Patent ↗Implantable biocompatible polymeric medical devices include a substrate with a plasma-modified surface which is subsequently modified to include click reactive members.
1. A medical device having a plasma-treated surface that is functionalized with a click reactive member to provide an activated surface on the medical device.
2. The medical device of claim 1 , wherein the medical device comprises a biodegradable polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof.
3. The method of claim 1 , wherein the medical device comprises a non-degradable polymer selected from fluorinated polymers, polyolefins, nylons, polyamides, polyurethanes, silicones, ultra high molecular weight polyethylene, polybutesters, polyaryletherketone, copolymers and combinations thereof.
4. The medical device of claim 1 , wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes.
5. The medical device of claim 1 , wherein the click reactive member comprises a thiol.
6. The medical device claim 1 , wherein the click reactive member comprises an azide.
7. The medical device of claim 1 , wherein the click reactive member comprises an alkyne.
8. The medical device of claim 1 , wherein the click reactive member comprises an alkene.
9. The medical device of claim 1 , wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.
10. A method of preparing a medical device having an activated surface, the method comprising:
plasma treating at least a portion of a surface of an absorbable polymeric medical device; and
attaching one or more click reactive members to the plasma treated surface of the absorbable polymeric medical device.
11. The method according to claim 10 , wherein the plasma treating provides reactive members on the surface of the medical device.
12. The method according to claim 10 , wherein the plasma treating provides a coating on the device, the coating including reactive members on the surface of the medical device.
13. The method according to claim 10 , wherein the medical device comprises a natural polymer selected from collagen, cellulose, poly (amino acids), polysaccharides, hyaluronic acid, gut, copolymers and combinations thereof.
14. The method according to claim 10 , wherein the click reactive member is selected from the group consisting of thiols, azides, alkynes and alkenes.
15. The method according to claim 10 , wherein the click reactive member comprises a thiol.
16. The method according to claim 10 , wherein the click reactive member comprises an azide.
17. The method according to claim 10 , wherein the click reactive member comprises an alkyne.
18. The method according to claim 10 , wherein the click reactive member comprises an alkene.
19. The method according to claim 10 , wherein the medical device is selected from the group consisting of monofilament sutures, multifilament sutures, surgical meshes, ligatures, sutures, staples, slings, patches, foams, pellicles, films, barriers, stents, catheters, and inflatable balloons.
20. The method according to claim 10 , wherein the medical device comprises a synthetic polymer.
21. The method according to claim 10 wherein the plasma treatment lasts less than 5 minutes.
22. The method according to claim 10 further comprising the step of combining the absorbable polymeric medical device with a drug functionalized with one or more complimentary click reactive members to covalently bond the drug to the surface of the absorbable polymeric substrate for drug delivery.