The present invention provides an antibody composition comprising ovine antibodies, for use in the prevention or treatment of C. difficile infection wherein the antibodies bind to a C. difficile toxin.
1. A method for treatment of Clostridium difficile infection, said method comprising administering a pharmaceutical composition, comprising:
ovine antibodies that bind to C. difficile Toxin A,
ovine antibodies that bind to C. difficile Toxin B, and
at least one component selected from the group consisting of a pharmaceutically acceptable carrier, excipient and salt for parenteral administration.
2. The method according to claim 1 , wherein the antibodies are polyclonal antibodies.
3. The method according to claim 1 , wherein the C. difficile Toxin A is selected from the group consisting of: Toxinotype 0, Toxinotype III and Toxinotype V.
4. The method according to claim 1 , wherein the C. difficile Toxin B is selected from the group consisting of: Toxinotype 0, Toxinotype III and Toxinotype V.
5. The method according to claim 1 , wherein the pharmaceutical composition further comprises ovine antibodies that bind to C. difficile Binary Toxin.
6. The method according to claim 5 , wherein the antibodies are polyclonal antibodies.