Composition and method for treating wounds
View Patent ↗Provided, among other things, is a method of treating a wound comprising: periodically applying to the wound over a course of days an effective amount of a water based formulation (comprising: 0.5 to 5 wt % of an emollient comprising silicone oil, 2 to 10 wt % of fatty acid, humectant(s), emulsifying agent(s), and polymer(s)), wherein the formulation is formulated as a spray, cream, lotion, milk or foam-former.
1. A method of accelerating wound closure in a mammalian subject, the method comprising:
administering topically an effective amount of a water-based formulation to a wound that is selected from the group consisting of incisions, abrasions, lacerations, penetration wounds, burns, ulcerations, surgical wounds, and piercing wounds, the water-based formulation comprising:
an emollient comprising a silicone oil or a petrolatum,
a fatty acid comprising stearic acid,
one or more humectants comprising one or more of a glycerol and a propylene glycol,
one or more emulsifying agents comprising polysorbate 20,
one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers, and
water,
wherein the water-based formulation is formulated as a spray, cream, lotion, milk or foam-former, and
wherein said administrating is for a time sufficient to substantially achieve wound closure.
2. The method of claim 1 , wherein the water-based formulation is applied as a foam using a propellant.
3. The method of claim 1 , wherein the water-based formulation is essentially free of C1 to C6 alcohols but not including polyols.
4. The method of claim 1 , wherein the water-based formulation further comprises a preservative.
5. The method of claim 1 , wherein the water-based formulation is free of preservatives.
6. The method of claim 2 , wherein the water-based formulation must be shaken prior to use.
7. The method of claim 2 , wherein the foam is stable at 35° C. for at least 1 min.
8. The method of claim 1 , wherein the water-based formulation is non-irritating.
9. The method of claim 1 , wherein the water-based formulation is non-sensitizing.
10. The method of claim 1 , wherein the water-based formulation is non-comedogenic.
11. The method of claim 1 , wherein the water-based formulation comprises, by weight % of the composition:
the one or more hydrophilic polymers in an amount in the range of 1.0-3.0%;
stearic acid in an amount in the range of 5.0-8.0%;
propylene glycol in an amount in the range of 4.0-7.0%;
glycerol in an amount in the range of 1.0-2.0%;
dimethicone in an amount in the range of 0.5-5.5%;
triethanolamine in an amount in the range of 0.1-3.0%;
polysorbate 20 in an amount in the range of 1.3-5.0%;
preservative in an amount in the range of 0.0-2.0%; and
water.
12. The method according to claim 1 , wherein the water-based formulation comprises:
0. 5 to 5 weight % of the emollient comprising silicone oil, and
2 to 10 weight % of fatty acid comprising stearic acid.
13. The method according to claim 1 , wherein the water-based formulation further comprises one or more titrants selected from a group consisting of triethanolamine, NaOH, citrate and phosphate.
14. The method according to claim 1 , wherein the administering comprises administering topically the water-based formulation two to three times a day to the wound in an amount of 1 to 5 mg/cm 2 .
15. The method of claim 1 , wherein the administering results in the reduction in the incidence of erythema and/or edema in the wound.
16. The method of claim 1 , wherein the silicone oil is polydimethylsiloxane.
17. The method of claim 1 , wherein the water-based formulation further comprises one or more humectants selected from a group consisting of polyols, excluding glycerol and propylene glycol, polydextrose and lactic acid.
18. The method of claim 1 , wherein the water-based formulation further comprises one or more emulsifying agents selected from a group consisting of sorbital fatty acid esters, octyl glucosides and pegylated lipids.
19. The method of claim 1 , wherein the wound extends the full thickness of the skin.
20. The method of claim 1 , wherein the water-based formulation does not contain an active anti-microbial ingredient.
21. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
one or more titrants; and
water.
22. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
one or more titrants;
one or more preservatives; and
water.
23. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
one or more titrants;
an active agent other than a microbial agent; and
water.
24. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
one or more titrants;
an active agent other than a microbial agent;
one or more preservatives; and
water.
25. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
one or more preservatives; and
water.
26. The method of claim 1 , wherein the water-based formulation consists of:
the emollient comprising the silicone or the petrolatum;
the fatty acid comprising stearic acid;
the one or more humectants comprising one or more of a glycerol and polypropylene glycol;
the one or more emulsifying agents comprising polysorbate 20;
the one or more hydrophilic polymers selected from the group consisting of: polyethylene glycol, starch, cellulose, and carbomers;
an active agent other than a microbial agent; and
water.