Compositions and methods for diagnosing and treating an inflammation
View Patent ↗A method of reducing an inflammatory response in a subject is provided. The method comprising providing to a subject in need thereof a therapeutically effective amount of an agent capable of reducing activity and/or expression of a scavenger receptor or of an effector thereof, thereby reducing the inflammatory response in the subject.
1. A method of treating Multiple Sclerosis (MS) in a subject in need thereof, the method comprising administering to said subject a therapeutically effective amount of an anti-SR-B1 antibody, thereby treating the Multiple Sclerosis in the subject.
2. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both in leukocytes.
3. The method of claim 1 , wherein said anti-SR-B1 antibody increases secretion of IL-10 in leukocytes.
4. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both, and increases secretion of IL-10 in leukocytes.
5. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both in macrophages.
6. The method of claim 1 , wherein said anti-SR-B1 antibody increases secretion of IL-10 in macrophages.
7. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both, and increases secretion of IL-10 in macrophages.
8. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both in T cells.
9. The method of claim 1 , wherein said anti-SR-B1 antibody increases secretion of IL-10 in T cells.
10. The method of claim 1 , wherein said anti-SR-B1 antibody reduces secretion of IL-12 or TNF-α or both, and increases secretion of IL-10 in T cells.