Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy

1. Aminoindane derivatives of the formula (I)

wherein

A is a 5- or 6-membered ring;

R is R 1 —W-A 1 -Q-Y-A 2 -X 1 —;

R 1 is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, halogenated C 1 -C 6 -alkyl, tri-(C 1 -C 4 -alkyl)-silyl-C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkyloxycarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylaminocarbonylamino-C 1 -C 4 -alkyl, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkyl, (optionally substituted C 6 -C 12 -aryl-C 1 -C 6 -alkyl)amino-C 1 -C 4 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl, optionally substituted C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl, C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, halogenated C 1 -C 6 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, (halogenated C 1 -C 4 -alkyl)aminocarbonyl, C 6 -C 12 -arylaminocarbonyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -hydroxyalkoxy, C 1 -C 6 -alkoxy-C 1 -C 4 -alkoxy, amino-C 1 -C 4 alkoxy, C 1 -C 6 -alkylamino-C 1 -C 4 -alkoxy, di-C 1 -C 6 -alkylamino-C 1 -C 4 alkoxy, C 1 -C 6 -alkylcarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylcarbonylamino-C 1 -C 4 -alkoxy, C 1 -C 6 -alkoxycarbonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylsulfonylamino-C 1 -C 4 -alkoxy, (halogenated C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 6 -C 12 -arylsulfonylamino-C 1 -C 4 -alkoxy, (C 6 -C 12 -aryl-C 1 -C 6 -alkyl)sulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclylsulfonylamino-C 1 -C 4 -alkoxy, C 3 -C 12 -heterocyclyl-C 1 -C 4 -alkoxy, C 6 -C 12 -aryloxy, C 3 -C 12 -heterocyclyloxy, C 1 -C 6 -alkylthio, halogenated C 1 -C 6 -alkylthio, C 1 -C 6 -alkylamino, (halogenated C 1 -C 6 -alkyl)amino, di-C 1 -C 6 -alkylamino, di-(halogenated C 1 -C 6 -alkyl)amino, C 1 -C 6 -alkylcarbonylamino, (halogenated C 1 -C 6 -alkyl)carbonylamino, C 6 -C 12 -arylcarbonylamino, C 1 -C 6 -alkylsulfonylamino, (halogenated C 1 -C 6 -alkyl)sulfonylamino, C 6 -C 12 -arylsulfonylamino or optionally substituted C 3 -C 12 -heterocyclyl;

W is —NR 8 — or a bond;

A 1 is optionally substituted C 1 -C 4 -alkylene or a bond;

Q is —S(O) 2 — or —C(O)—;

Y is —NR 9 — or a bond;

A 2 is optionally substituted C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-CO—, —CO—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-O—C 1 -C 4 -alkylene, C 1 -C 4 -alkylene-NR 10 —C 1 -C 4 -alkylene, optionally substituted C 2 -C 4 -alkenylen, optionally substituted C 2 -C 4 -alkynylene, optionally substituted C 6 -C 12 -arylene, optionally substituted C 6 -C 12 -heteroarylene or a bond;

X 1 is —O—, —NR 11 —, —S—, optionally substituted C 1 -C 4 -alkylene, optionally substituted C 2 -C 4 -alkenylen, or optionally substituted C 2 -C 4 -alkynylene;

R 2 is hydrogen, halogen, C 1 -C 6 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, —CN, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, optionally substituted C 6 -C 12 -aryl, hydroxy, C 1 -C 6 -alkoxy, halogenated C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxy, C 6 -C 12 -aryl-C 1 -C 4 -alkoxy, C 1 -C 6 -alkylcarbonyloxy, C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl, aminosulfonyl, amino, C 1 -C 6 -alkylamino, C 2 -C 6 -alkenylamino, nitro or optionally substituted C 3 -C 12 -heterocyclyl, or two radicals R 2 together with the ring atoms of A to which they are bound form a 5- or 6 membered ring;

R 3 is hydrogen, halogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkoxy, or two radicals R 3 together with the carbon atom to which they are attached form a carbonyl group;

R 4a is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, C 6 -C 12 -aryl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl, —CHO, C 1 -C 4 -alkylcarbonyl, (halogenated C 1 -C 4 -alkyl)carbonyl, C 6 -C 12 -arylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl;

R 4b is hydrogen, C 1 -C 6 -alkyl, halogenated C 1 -C 4 -alkyl, hydroxy-C 1 -C 4 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 4 -alkyl, amino-C 1 -C 4 -alkyl, CH 2 CN, —CHO, C 1 -C 4 -alkylcarbonyl, (halogenated C 1 -C 4 -alkyl)carbonyl, C 6 -C 12 -arylcarbonyl, C 1 -C 4 -alkoxycarbonyl, C 6 -C 12 -aryloxycarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 2 -C 6 -alkenyl, —C(═NH)NH 2 , —C(═NH)NHCN, C 1 -C 6 -alkylsulfonyl, C 6 -C 12 -arylsulfonyl, amino, —NO or C 3 -C 12 -heterocyclyl; or

R 4a , R 4b together are optionally substituted C 1 -C 6 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 16 ;

X 2 is —O—, —NR 6 —, —S—, >CR 12a R 12b or a bond;

X 3 is —O—, —NR 7 —, —S—, >CR 13a R 13b or a bond;

R 5 is optionally substituted C 6 -C 12 -aryl, optionally substituted C 3 -C 12 -cycloalkyl or optionally substituted C 3 -C 12 -heterocyclyl;

R 6 is hydrogen or C 1 -C 6 -alkyl;

R 7 is hydrogen or C 1 -C 6 -alkyl;

R 8 is hydrogen or C 1 -C 6 -alkyl;

R 9 is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl, amino-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl-C 1 -C 4 -alkyl or C 3 -C 12 -heterocyclyl; or

R 9 , R 1 together are C 1 -C 4 -alkylene; or

R 9 is C 1 -C 4 -alkylene that is bound to a carbon atom in A 2 and A 2 is C 1 -C 4 -alkylene or to a carbon atom in X 1 and X 1 is C 1 -C 4 -alkylene;

R 10 is hydrogen, C 1 -C 6 -alkyl or C 1 -C 6 -alkylsulfonyl;

R 11 is hydrogen or C 1 -C 6 -alkyl, or

R 9 , R 11 together are C 1 -C 4 -alkylene,

R 12a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy;

R 12b is hydrogen or C 1 -C 6 -alkyl, or

R 12a , R 12b together are carbonyl or optionally substituted C 1 -C 4 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 14 —;

R 13a is hydrogen, optionally substituted C 1 -C 6 -alkyl, C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, di-C 1 -C 6 -alkylamino-C 1 -C 4 -alkyl, C 3 -C 12 -heterocyclyl-C 1 -C 6 -alkyl, optionally substituted C 6 -C 12 -aryl or hydroxy;

R 13b is hydrogen or C 1 -C 6 -alkyl, or

R 13a , R 13b together are carbonyl or optionally substituted C 1 -C 4 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom or —NR 15 -;

R 14 is hydrogen or C 1 -C 6 -alkyl;

R 15 is hydrogen or C 1 -C 6 -alkyl; and

R 16 is hydrogen or C 1 -C 6 -alkyl,

or a physiologically tolerated salt thereof.

2. Compound as claimed in claim 1 , wherein A is a benzene ring.

3. Compound as claimed in claim 1 , wherein —Y-A 2 -X 1 — comprises at least 2, 3 or 4 atoms in the main chain.

4. Compound as claimed in claim 1 , wherein R 1 is C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl, or optionally substituted C 3 -C 12 -heterocyclyl.

5. Compound as claimed in claim 1 , wherein A 1 is a bond.

6. Compound as claimed in claim 1 , wherein W is a bond and Y is a bond, or W is a bond and Y is —NR 9 —.

7. Compound as claimed in claim 1 , wherein X 1 is —O— and A 2 is C 1 -C 4 -alkylene, or X 1 is C 1 -C 4 -alkylene and A 2 is a bond.

8. Compound as claimed in claim 1 , wherein R 1 —W-A 1 -Q-Y-A 2 -X 1 — is R 1 —S(O) 2 —NR 9 -A 2 -X 1 — or R 1 —S(O) 2 —X 1 —.

9. Compound as claimed in claim 1 , having the formula

wherein R 1 , W, A 1 , Q, Y, A 2 , X 1 , R 2 , R 3 , R 4a , R 4b , X 2 , X 3 , and R 5 are as defined in claim 1 .

10. Compound as claimed in claim 1 , wherein R 4a is C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl, C 1 -C 4 -alkoxycarbonyl or C 3 -C 12 -heterocyclyl.

11. Compound as claimed in claim 1 , wherein R 4b is hydrogen.

12. Compound as claimed in claim 1 , wherein R 4a , R 4b together are optionally substituted C 1 -C 6 -alkylene, wherein one —CH 2 — of C 1 -C 6 -alkylene may be replaced by an oxygen atom.

13. Compound as claimed in claim 1 , wherein X 2 is CR 12a R 12b and X 3 is a bond.

14. Compound as claimed in claim 1 , wherein R 12a is hydrogen or C 1 -C 6 -alkyl and R 12b is hydrogen or C 1 -C 6 -alkyl, or R 12a , R 12b together are optionally substituted C 1 -C 4 -alkylene.

15. Compound as claimed in claim 1 , wherein R 5 is optionally substituted aryl.

16. Compound as claimed in claim 1 , having the formula

wherein A, R, R 2 , R 3 , R 4a , R 4b , X 2 , X 3 are as defined in claim 1 ; and

R 17a , R 17b , R 17c , R 17d , R 17e independently are hydrogen, halogen, or halogenated C 1 -C 6 -alkyl.

17. Compound as claimed in claim 1 , wherein

A is a benzene ring;

R is R 1 —W-A 1 -Q-Y-A 2 -X 1 —;

R 1 is C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl-C 1 -C 4 -alkyl, C 3 -C 12 -cycloalkyl, or optionally substituted C 3 -C 12 -heterocyclyl;

W is a bond;

A 1 is a bond;

Q is —S(O) 2 —;

Y is —NR 9 — or a bond;

A 2 is C 1 -C 4 -alkylene or a bond;

X 1 is —O— or C 1 -C 4 -alkylene;

R 2 is hydrogen or halogen;

R 3 is hydrogen;

R 4a is hydrogen, C 1 -C 6 -alkyl, C 3 -C 12 -cycloalkyl, C 1 -C 4 -alkoxycarbonyl or C 3 -C 12 -heterocyclyl;

R 4b is hydrogen; or

R 4a , R 4b together are optionally substituted C 1 -C 6 -alkylene, wherein one —CH 2 — of C 1 -C 4 -alkylene may be replaced by an oxygen atom;

X 2 is CR 12a R 12b ;

X 3 is a bond;

R 5 is optionally substituted phenyl;

R 9 is hydrogen; or

R 9 is C 1 -C 4 -alkylene that is bound to a carbon atom in X 1 and X 1 is C 1 -C 4 -alkylene;

R 12a is hydrogen; and

R 12b is hydrogen; or

R 12a , R 12b together are C 1 -C 4 -alkylene.

18. The compound as claimed in claim 1 , which is:

N-(2-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

1-benzyl-6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

1-benzyl-6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-11-methyl-1H-imidazole-4-sulfonamide;

1-benzyl-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-benzyl-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

1-benzyl-6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

1-benzyl-6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

1-benzyl-5-fluoro-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((3-benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-benzyl-5-fluoro-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)methyl)-cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)-azetidine;

N-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

1-cyclopropyl-N-(2-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)methanesulfonamide;

N-(2-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-cyclopropyl-N-((3-(3-fluorobenzyI)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)methanesulfonamide;

1-(3-fluorobenzyl)-6-(1-((cyclopropylm ethyl)sulfonyl)azetidin-3-yl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-1-(3-fluorobenzyl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

1-(3-fluorobenzyl)-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-(3-fluorobenzyl)-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

1-cyclopropyl-N-(2-((6-fluoro-3-(3-fluorobenzyI)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)methanesulfonamide;

N-(2-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-cyclopropyl-N-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)methanesulfonamide;

6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-5-fluoro-1-(3-fluorobenzyl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-5-fluoro-1-(3-fluorobenzyl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

5-fluoro-1-(3-fluorobenzyl)-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((6-fluoro-3-(3-fluorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

5-fluoro-1-(3-fluorobenzyl)-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-(3-fluorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-6-fluoro-3-(3-fluorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

1-(3-chlorobenzyl)-6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

1-(3-chlorobenzyl)-6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

1-(3-chlorobenzyl)-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-(3-chlorobenzyl)-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

1-(3-chlorobenzyl)-6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

1-(3-chlorobenzyl)-6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

1-(3-chlorobenzyl)-5-fluoro-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-((3-(3-chlorobenzyl)-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-(3-chlorobenzyl)-5-fluoro-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-chlorobenzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

1-cyclopropyl-N-(2-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)methanesulfonamide;

N-(2-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

1-methyl-N-(2-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1H-imidazole-4-sulfonamide;

1-methyl-N-(2-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1H-pyrazole-4-sulfonamide;

1-cyclopropyl-N-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)methanesulfonamide;

6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-N-methyl-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

N-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-N-methyl-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

1-methyl-N-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1H-imidazole-4-sulfonamide;

N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

1-methyl-N-((2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1H-pyrazole-4-sulfonamide;

N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

1-cyclopropyl-N-(2-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)methanesulfonamide;

N-(2-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

1-cyclopropyl-N-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)methanesulfonamide;

6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

6-(1-((cyclopropylmethyl)sulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

6-(1-(cyclobutylsulfonyl)azetidin-3-yl)-5-fluoro-N-methyl-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

N-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

5-fluoro-N-methyl-6-(1-((1-methyl-1H-imidazol-4-yl)sulfonyl)azetidin-3-yl)-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

N-((6-fluoro-2-(methylamino)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

5-fluoro-N-methyl-6-(1-((1-methyl-1H-pyrazol-4-yl)sulfonyl)azetidin-3-yl)-1-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-2-amine;

N-(2-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-((2-(azetidin-1-yl)-3-(3-trifluoromethyl)benzyl)-6-fluoro-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-cyclopropylmethanesulfonamide;

N-(2-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)cyclobutanesulfonamide;

N-(2-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)oxy)ethyl)-1-methyl-1H-pyrazole-4-sulfonamide;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-cyclopropylmethanesulfonamide;

3-(2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)-1-((cyclopropylmethyl)sulfonyl)azetidine;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)cyclobutanesulfonamide;

3-(2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)-1-(cyclobutylsulfonyl)azetidine;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-6-fluoro-3-(3-trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-imidazole;

N-((2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-pyrazole-4-sulfonamide;

4-((3-(2-(azetidin-1-yl)-6-fluoro-3-(3-(trifluoromethyl)benzyl)-2,3-dihydro-1H-inden-5-yl)azetidin-1-yl)sulfonyl)-1-methyl-1H-pyrazole;

N-(2-(2-amino-3-benzyl-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

cis-N-(2-(2-Amino-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

Ethyl 1-benzyl-6-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-ylcarbamate;

Ethyl 1-benzyl-6-(2-(1-methyl-1H-imidazole-2-sulfonamido)ethoxy)-2,3-dihydro-1H-inden-2-ylcarbamate;

N-{2-[(2-amino-3-benzyl-2,3-dihydro-1H-inden-5-yl)oxy]ethyl}-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-(2-Amino-3-benzyl-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-2-sulfonamide;

N-(2-(3-Benzyl-2-(methylamino)-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

cis-N-(2-(3-Benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

cis-N-(2-{[2-(azetidin-1-yl)-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-(2-(Azetidin-1-yl)-3-benzyl-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-(3-Benzyl-6-fluoro-2-(3-methylazetidin-1-yl)-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-(3-Benzyl-2-(3-methylazetidin-1-yl)-2,3-dihydro-1H-inden-5-yloxy)ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-{[3-Benzyl-2-(3,3-dimethylazetidin-1-yl)-2,3-dihydro-1H-inden-5-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

cis-N-(2-{[3-benzyl-6-fluoro-2-(3-hydroxy-3-methylazetidin-1-yl)-2,3-dihydro-1H-inden-5-yl]oxy}ethyl)-1-methyl-1H-imidazole-4-sulfonamide;

N-(2-(3-Benzyl-6-fluoro-2-(3-hydroxy-3-methylazetidin-1-yl)-2,3-dihydro-1H-inden-5-yloxy)ethyl)-N,1-dimethyl-1H-imidazole-4-sulfonamide;

Ethyl 1-Benzyl-5-fluoro-6-((1-methyl-1H-imidazole-4-sulfonamido)methyl)-2,3-dihydro-1H-inden-2-ylcarbamate;

cis-N-{[3-Benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide;

trans-N-{[3-Benzyl-6-fluoro-2-(methylamino)-2,3-dihydro-1H-inden-5-yl]methyl}-1-methyl-1H-imidazole-4-sulfonamide; or

cis-N-((2-Amino-3-benzyl-6-fluoro-2,3-dihydro-1H-inden-5-yl)methyl)-1-methyl-1H-imidazole-4-sulfonamide;

or a physiologically tolerated salt thereof.

19. Pharmaceutical composition which comprises a carrier and a compound of claim 1 .