Methods for imaging ocular devices using optical coherence tomography
View Patent ↗Described herein are methods for imaging ocular devices. The methods generally involve (a) applying a scattering agent to the ocular device; and (b) imaging the ocular device using optical coherence tomography (OCT). The methods described herein provide useful structural information about the surface of the device with high sensitivity.
1. A method for imaging an ocular device comprising:
a. applying a scattering agent to the ocular device, wherein the scattering agent comprises a pigment;
b. rinsing the device;
c. submerging the device in a solution of water, saline, or a buffered solution; and
d. imaging the ocular device using optical coherence tomography (OCT).
2. The method of claim 1 , wherein the pigment comprises Green Cr 2 O 3 , Yellow Iron Oxide, or any combination thereof.
3. The method of claim 2 , wherein the ocular device is a contact lens.
4. The method of claim 2 , wherein the ocular device is an intraocular lens.
5. The method of claim 1 , wherein the pigment comprises a water-insoluble salt that forms in situ on the surface of the device, throughout the device, or a combination thereof.
6. The method of claim 5 , wherein the water-insoluble salt comprises a silver salt.
7. The method of claim 3 , wherein the ocular device is a contact lens.
8. The method of claim 1 , wherein step (a) comprises submerging the ocular device in a solution comprising the scattering agent.
9. The method of claim 8 , wherein the ocular device is imaged in a solution of the scattering agent.
10. The method of claim 1 , wherein the ocular device is imaged in a solution of the scattering agent.
11. The method of claim 1 , wherein the device is imaged by a Frequency Domain OCT, Fourier-domain OCT (FDOCT), complex Fourier OCT, Optical Frequency-domain imaging, or swept-source OCT.
12. The method of claim 1 , wherein the ocular device is a contact lens.
13. The method of claim 1 , wherein the ocular device is an intraocular lens.