Surface induced ring-opening polymerization and medical devices formed therefrom
View Patent ↗The present disclosure relates to coated biodegradable materials having a reduced amount of residual catalysts and methods thereof.
1. A method of reducing residual catalyst from a biodegradable polymeric material comprising:
providing a container which includes at least one monomer capable of polymerizing via cationic ring-opening polymerization and a biodegradable polymeric material containing a residual catalyst; and
heating the container with the biodegradable polymeric material and the at least one monomer above the glass transition temperature and below the crystallization temperature of the biodegradable polymeric material to release the residual catalyst from the biodegradable polymeric material; and,
polymerizing the monomer with the released residual catalyst at the temperature above the glass transition temperature and below the crystallization temperature of the biodegradable polymeric material.
2. The method of claim 1 wherein the at least one monomer comprises a cyclic ester.
3. The method of claim 2 wherein the cyclic ester comprises an aliphatic cyclic ester.
4. The method of claim 2 wherein the cyclic ester is selected from the group consisting of lactide, glycolide, p-dioxanone, ε-caprolactone, methyl-tetrahydrofuran, ω-pentadecalactone, ω-dodecalactone, δ-valerolactone, β-methyl-β-propiolactone, α-methyl-β-propiolactone, γ-butyrolactone, trimethylene carbonate, tetramethylene carbonate, 2,2-dimethyl trimethylene carbonate and combinations thereof.
5. The method of claim 1 wherein the biodegradable polymeric material is selected from the group consisting of poly-L-lactide, poly-DL-lactide, poly(lactic-co-glycolic acid), poly(glycolic acid), poly(p-dioxanone), poly(ε-caprolactone), poly(trimethylene carbonate), poly(tetramethylene carbonate), poly(hydroxylalkanoates), and combinations thereof.
6. The method of claim 1 wherein the biodegradable polymeric material comprises a biodegradable pellet.
7. The method of claim 1 , wherein the residual catalyst comprises stannous octoate.
8. The method of claim 1 wherein the container is positioned in an oven from about 30 minutes to about 10 days.
9. The method, of claim 1 wherein the container is positioned in an oven from about 6 hours to about 5 days.
10. The method of claim 1 wherein no additional catalyst is used.
11. The method of claim 7 wherein polymerizing the monomer with the released residual catalyst occurs at the temperature above the glass transition temperature and below the crystallization temperature of the biodegradable polymeric material.
12. The method of claim 7 wherein no additional catalyst is used.